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About:
A Recombinant Vaccine of H5N1 HA1 Fused with Foldon and Human IgG Fc Induced Complete Cross-Clade Protection against Divergent H5N1 Viruses
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An Entity of Type :
schema:ScholarlyArticle
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covidontheweb.inria.fr
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Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
A Recombinant Vaccine of H5N1 HA1 Fused with Foldon and Human IgG Fc Induced Complete Cross-Clade Protection against Divergent H5N1 Viruses
Creator
Du, Lanying
Jiang, Shibo
Zhao, Guangyu
Zheng, Bo-Jian
Zhou, Yusen
Zhou, Jie
Cai, Lifeng
Chen, Min
He, Wu
Sun, Shihui
Zhang, Hai-Ying
Zhang, Xiujuan
Leung, Ho-Chuen
Chan, Chris
Kwok-Man Poon, Vincent
Source
Medline; PMC
abstract
Development of effective vaccines to prevent influenza, particularly highly pathogenic avian influenza (HPAI) caused by influenza A virus (IAV) subtype H5N1, is a challenging goal. In this study, we designed and constructed two recombinant influenza vaccine candidates by fusing hemagglutinin 1 (HA1) fragment of A/Anhui/1/2005(H5N1) to either Fc of human IgG (HA1-Fc) or foldon plus Fc (HA1-Fdc), and evaluated their immune responses and cross-protection against divergent strains of H5N1 virus. Results showed that these two recombinant vaccines induced strong immune responses in the vaccinated mice, which specifically reacted with HA1 proteins and an inactivated heterologous H5N1 virus. Both proteins were able to cross-neutralize infections by one homologous strain (clade 2.3) and four heterologous strains belonging to clades 0, 1, and 2.2 of H5N1 pseudoviruses as well as three heterologous strains (clades 0, 1, and 2.3.4) of H5N1 live virus. Importantly, immunization with these two vaccine candidates, especially HA1-Fdc, provided complete cross-clade protection against high-dose lethal challenge of different strains of H5N1 virus covering clade 0, 1, and 2.3.4 in the tested mouse model. This study suggests that the recombinant fusion proteins, particularly HA1-Fdc, could be developed into an efficacious universal H5N1 influenza vaccine, providing cross-protection against infections by divergent strains of highly pathogenic H5N1 virus.
has issue date
2011-01-27
(
xsd:dateTime
)
bibo:doi
10.1371/journal.pone.0016555
bibo:pmid
21304591
has license
cc-by
sha1sum (hex)
61e9b0e59092872671011d724f22401d3c2f8288
schema:url
https://doi.org/10.1371/journal.pone.0016555
resource representing a document's title
A Recombinant Vaccine of H5N1 HA1 Fused with Foldon and Human IgG Fc Induced Complete Cross-Clade Protection against Divergent H5N1 Viruses
has PubMed Central identifier
PMC3029370
has PubMed identifier
21304591
schema:publication
PLoS One
resource representing a document's body
covid:61e9b0e59092872671011d724f22401d3c2f8288#body_text
is
schema:about
of
named entity 'highly'
named entity 'divergent'
named entity 'study'
named entity 'H5N1'
named entity 'study'
named entity 'clades'
named entity 'mouse'
named entity 'H5N1'
named entity 'strains'
named entity 'IAV'
named entity 'virus'
named entity 'virus'
named entity 'heterologous'
named entity 'RECOMBINANT VACCINE'
named entity '2.2'
named entity 'STRAIN'
named entity 'HEMAGGLUTININ'
named entity 'FRAGMENT OF'
named entity '3.4'
named entity 'HA1'
named entity 'VIRUSES'
named entity 'LIVE'
named entity 'PROVIDED'
named entity 'HUMAN IGG'
named entity 'VACCINE'
named entity 'COULD BE'
named entity 'RECOMBINANT VACCINE'
named entity 'STUDY'
named entity 'HIGH-DOSE'
named entity 'PROTECTION'
named entity 'LETHAL'
named entity 'DIFFERENT'
named entity 'SUBTYPE'
named entity 'IMMUNIZATION'
named entity 'HIGHLY PATHOGENIC AVIAN INFLUENZA'
named entity 'BELONGING'
named entity 'ZHANG'
named entity 'H5N1'
named entity 'PROVIDING'
named entity 'DEVELOPMENT'
named entity 'STRONG'
named entity 'THEIR'
named entity 'PROTEINS'
named entity 'HOMOLOGOUS'
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named entity 'VACCINATED'
named entity 'CHALLENGE'
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covid:arg/61e9b0e59092872671011d724f22401d3c2f8288
named entity 'CLADE'
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named entity 'HUMAN IGG'
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named entity 'PROTECTION'
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