About: Human encephalitis caused by pseudorabies virus infection: a case report

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Human encephalitis caused by pseudorabies virus infection: a case report
Creator	Guo, Wei Li, Ping Wang, Di Chen, Jian Wang, Jinquan Fei, Mingming Tao, Xiaogen
source	PMC
abstract	Pseudorabies virus (PRV) primarily infects swine but can infect cattle, dogs, and cats. Several studies have reported that PRV can cross the specie barrier and induce human encephalitis, but a definitive diagnosis of human PRV encephalitis is debatable due to the lack of PRV DNA detection. Here, we report a case of human PRV encephalitis diagnosed by the next-generation sequencing (NGS) of PRV sequences in the cerebrospinal fluid (CSF) of a patient. A male pork vendor developed fever and seizures for 6 days. NGS results showed PRV sequences in his CSF and blood. Sanger sequencing showed that PRV DNA in the CSF and PRV antibodies in both the CSF and blood were positive. MRI results revealed multiple inflammatory lesions in the bilateral hemisphere. Based on the clinical and laboratory data, we diagnosed the patient with PRV encephalitis. This case suggests that PRV can infect humans, causing severe viral encephalitis. People at risk of PRV infection should improve their self-protection awareness.
has issue date	2020-01-02(xsd:dateTime)
bibo:doi	10.1007/s13365-019-00822-2
bibo:pmid	31898060
has license	no-cc
sha1sum (hex)	61e282daaa28576b521af2bb60995638d11fe839
schema:url	https://doi.org/10.1007/s13365-019-00822-2
resource representing a document's title	Human encephalitis caused by pseudorabies virus infection: a case report
has PubMed Central identifier	PMC7223082
has PubMed identifier	31898060
schema:publication	J Neurovirol
resource representing a document's body	covid:61e282daaa28576b521af2bb60995638d11fe839#body_text
is schema:about of	named entity 'PRV' named entity 'lesions' named entity 'encephalitis' named entity 'specie' named entity 'infect' named entity 'patient' named entity 'MRI' named entity 'improve' named entity 'case' named entity 'male' named entity 'INFLAMMATORY' named entity 'DETECTION' named entity 'PRV' named entity 'awareness' named entity 'CSF' named entity 'severe' named entity 'PRV' named entity 'encephalitis' named entity 'PRV' named entity 'detection' named entity 'Here' named entity 'pork' named entity 'viral encephalitis' named entity 'NGS' named entity 'PRV' named entity 'encephalitis' named entity 'Sanger' named entity 'case report' named entity 'infection' named entity 'rubella virus' named entity 'coma' named entity 'acyclovir' named entity 'viral encephalitis' named entity 'ventilator' named entity 'antiviral therapy' named entity 'IgG' named entity 'real-time PCR' named entity 'NGS' named entity 'acyclovir' named entity 'GBM' named entity 'next-generation sequencing' named entity 'central nervous' named entity 'plasma' named entity 'fever' named entity 'EEG' named entity 'Eastern China' named entity 'organ' named entity 'infection' named entity 'lumbar punctures' named entity 'inflammatory' named entity 'coma' named entity 'Infectious Diseases Society of America' named entity 'China' named entity 'basal ganglia' named entity 'empirical treatment' named entity 'basal ganglia' named entity 'MRI' named entity 'PRV' named entity 'parietal lobe' named entity 'PRV' named entity 'polymerase chain reaction' named entity 'antinuclear antibodies' named entity 'PCR' named entity 'Hefei' named entity 'staining' named entity 'limbic' named entity 'methylprednisolone' named entity 'glucose' named entity 'chills' named entity 'virus' named entity 'follow-up' named entity 'encephalitis' named entity 'blood sample' named entity 'C-reactive protein' named entity 'pig'

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