About: Virus characterization and discovery in formalin-fixed paraffin-embedded tissues

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Virus characterization and discovery in formalin-fixed paraffin-embedded tissues
Creator	Kuiken, Thijs Osterhaus, Albert Koopmans, Marion Baumgärtner, Wolfgang Bodewes, Rogier Schürch, Anita Smits, Saskia Van Run, Peter
source	Elsevier; Medline; PMC
abstract	Detection and characterization of novel viruses is hampered frequently by the lack of properly stored materials. Especially for the retrospective identification of viruses responsible for past disease outbreaks, often only formalin-fixed paraffin-embedded (FFPE) tissue samples are available. Although FFPE tissues can be used to detect known viral sequences, the application of FFPE tissues for detection of novel viruses is currently unclear. In the present study it was shown that sequence-independent amplification in combination with next-generation sequencing can be used to detect sequences of known and unknown viruses, although with relatively low sensitivity. These findings indicate that this technique could be useful for detecting novel viral sequences in FFPE tissues collected from humans and animals with disease of unknown origin, when other samples are not available. In addition, application of this method to FFPE tissues allows to correlate with the presence of histopathological changes in the corresponding tissue sections.
has issue date	2015-03-15(xsd:dateTime)
bibo:doi	10.1016/j.jviromet.2015.02.002
bibo:pmid	25681526
has license	no-cc
sha1sum (hex)	61b2684ad561180c3fb6683f0644b13b20d7136b
schema:url	https://doi.org/10.1016/j.jviromet.2015.02.002
resource representing a document's title	Virus characterization and discovery in formalin-fixed paraffin-embedded tissues
has PubMed Central identifier	PMC7119673
has PubMed identifier	25681526
schema:publication	J Virol Methods
resource representing a document's body	covid:61b2684ad561180c3fb6683f0644b13b20d7136b#body_text
is schema:about of	named entity 'histopathological' named entity 'addition' named entity 'tissue' named entity 'TISSUES' named entity 'VIRUS' named entity 'NOT AVAILABLE' named entity 'ANIMALS' named entity 'DISCOVERY' named entity 'USED' named entity 'TISSUE' named entity 'KNOWN' named entity 'NEXT-GENERATION SEQUENCING' named entity 'COULD BE' named entity 'SEQUENCES' named entity 'MATERIALS' named entity 'PAST' named entity 'RETROSPECTIVE' named entity 'INDEPENDENT' named entity 'DETECTING' named entity 'COMBINATION' named entity 'HISTOPATHOLOGICAL' named entity 'RESPONSIBLE' named entity 'FINDINGS' covid:arg/61b2684ad561180c3fb6683f0644b13b20d7136b named entity 'FREQUENTLY' named entity 'DISEASE' named entity 'COLLECTED' named entity 'LACK' named entity 'APPLICATION' named entity 'SAMPLES' named entity 'TECHNIQUE' named entity 'CHANGES' named entity 'TO DETECT' named entity 'NOVEL' named entity 'ALLOWS' named entity 'CHARACTERIZATION' named entity 'FORMALIN-FIXED PARAFFIN-EMBEDDED' named entity 'THESE' named entity 'STORED' named entity 'IDENTIFICATION' named entity 'UNKNOWN ORIGIN' named entity 'ADDITION' named entity 'PRESENT' named entity 'TISSUES' named entity 'AMPLIFICATION' named entity 'UNKNOWN' named entity 'VIRUSES' named entity 'STUDY' named entity 'SENSITIVITY' named entity 'LOW' named entity 'UNCLEAR' named entity 'FORMALIN-FIXED PARAFFIN-EMBEDDED' named entity 'HUMANS' named entity 'CURRENTLY' named entity 'VIRAL' named entity 'DETECTION' named entity 'AVAILABLE' named entity 'USEFUL' named entity 'SEQUENCE' named entity 'METHOD' named entity 'CHARACTERIZATION' named entity 'DISEASE OUTBREAKS' named entity 'samples' named entity 'viruses' named entity 'viral' named entity 'next-generation sequencing' named entity 'properly' named entity 'sequences' named entity 'viruses' named entity 'low sensitivity' named entity 'disease outbreaks' named entity 'paraffin' named entity 'formalin-fixed' named entity 'tissue sections'

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