About: SARS-like cluster of circulating bat coronavirus pose threat for human emergence

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SARS-like cluster of circulating bat coronavirus pose threat for human emergence
Creator	Lanzavecchia, Antonio Baric, Ralph Gralinski, Lisa Agnihothram, Sudhakar Yount, Boyd Ge, Xing-Yi Donaldson, Eric Scobey, Trevor Plante, Jessica Debbink, Kari Menachery, Vineet Shi, Zhengli-Li Graham, Rachel Marasco, Wayne Randell, Scott
source	Medline; PMC; WHO
abstract	The emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome (MERS)-CoV underscores the threat of cross-species transmission events leading to outbreaks in humans. In this study, we examine the disease potential for SARS-like CoVs currently circulating in Chinese horseshoe bat populations. Utilizing the SARS-CoV infectious clone, we generated and characterized a chimeric virus expressing the spike of bat coronavirus SHC014 in a mouse adapted SARS-CoV backbone. The results indicate that group 2b viruses encoding the SHC014 spike in a wild type backbone can efficiently utilize multiple ACE2 receptor orthologs, replicate efficiently in primary human airway cells, and achieve in vitro titers equivalent to epidemic strains of SARS-CoV. Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis. Evaluation of available SARS-based immune-therapeutic and prophylactic modalities revealed poor efficacy; both monoclonal antibody and vaccine approaches failed to neutralize and protect from CoVs utilizing the novel spike protein. Importantly, based on these findings, we synthetically rederived an infectious full length SHC014 recombinant virus and demonstrate robust viral replication both in vitro and in vivo. Together, the work highlights a continued risk of SARS-CoV reemergence from viruses currently circulating in bat populations.
has issue date	2015-11-09(xsd:dateTime)
bibo:doi	10.1038/nm.3985
bibo:pmid	26552008
has license	bronze-oa
sha1sum (hex)	61a636a30861be88d728c2dc6150ba35fa719ecb
schema:url	https://doi.org/10.1038/nm.3985
resource representing a document's title	SARS-like cluster of circulating bat coronavirus pose threat for human emergence
has PubMed Central identifier	PMC4797993
has PubMed identifier	26552008
schema:publication	Nature Medicine
resource representing a document's body	covid:61a636a30861be88d728c2dc6150ba35fa719ecb#body_text
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