About: Delineation of the intricacies of protein function from macromolecular structure constitutes a continual obstacle in the study of cell and pathogen biology. Structure-based phylogenetic analysis has emerged as a powerful tool for addressing this challenge, allowing the detection and quantification of conserved architectural properties between proteins, including those with low or no detectable sequence homology. With a focus on viral protein structure, we highlight how a number of investigations have utilized this powerful method to infer common functionality and ancestry.   Goto Sponge  NotDistinct  Permalink

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  • Delineation of the intricacies of protein function from macromolecular structure constitutes a continual obstacle in the study of cell and pathogen biology. Structure-based phylogenetic analysis has emerged as a powerful tool for addressing this challenge, allowing the detection and quantification of conserved architectural properties between proteins, including those with low or no detectable sequence homology. With a focus on viral protein structure, we highlight how a number of investigations have utilized this powerful method to infer common functionality and ancestry.
Subject
  • Virology
  • Proteomics
  • Proteins
  • Biochemistry
  • Phylogenetics
  • Macromolecules
  • Infectious diseases
  • Viral proteins
  • Medicinal chemistry
  • Drug discovery
  • Polymers
  • Design of experiments
  • Evolutionary biology
  • Molecular biology
  • Polymer chemistry
  • Molecular physics
  • Evolutionary developmental biology
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