About: Genomic Analysis of 15 Human Coronaviruses OC43 (HCoV-OC43s) Circulating in France from 2001 to 2013 Reveals a High Intra-Specific Diversity with New Recombinant Genotypes

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About: Genomic Analysis of 15 Human Coronaviruses OC43 (HCoV-OC43s) Circulating in France from 2001 to 2013 Reveals a High Intra-Specific Diversity with New Recombinant Genotypes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genomic Analysis of 15 Human Coronaviruses OC43 (HCoV-OC43s) Circulating in France from 2001 to 2013 Reveals a High Intra-Specific Diversity with New Recombinant Genotypes
Creator	Vabret, Astrid Miszczak, Fabien Kin, Nathalie Lin, Wei Gouilh, Meriadeg Consortium, Epicorem
Source	Medline; PMC
abstract	Human coronavirus OC43 (HCoV-OC43) is one of five currently circulating human coronaviruses responsible for respiratory infections. Like all coronaviruses, it is characterized by its genome’s high plasticity. The objectives of the current study were to detect genetically distinct genotypes and eventually recombinant genotypes in samples collected in Lower Normandy between 2001 and 2013. To this end, we sequenced complete nsp12, S, and N genes of 15 molecular isolates of HCoV-OC43 from clinical samples and compared them to available data from the USA, Belgium, and Hong-Kong. A new cluster E was invariably detected from nsp12, S, and N data while the analysis of nsp12 and N genes revealed the existence of new F and G clusters respectively. The association of these different clusters of genes in our specimens led to the description of thirteen genetically distinct genotypes, among which eight recombinant viruses were discovered. Identification of these recombinant viruses, together with temporal analysis and tMRCA estimation, provides important information for understanding the dynamics of the evolution of these epidemic coronaviruses.
has issue date	2015-05-07(xsd:dateTime)
bibo:doi	10.3390/v7052358
bibo:pmid	26008694
has license	cc-by
sha1sum (hex)	616eb9a60a8da572b0a60b6d33f4618c91c7b55c
schema:url	https://doi.org/10.3390/v7052358
resource representing a document's title	Genomic Analysis of 15 Human Coronaviruses OC43 (HCoV-OC43s) Circulating in France from 2001 to 2013 Reveals a High Intra-Specific Diversity with New Recombinant Genotypes
has PubMed Central identifier	PMC4452910
has PubMed identifier	26008694
schema:publication	Viruses
resource representing a document's body	covid:616eb9a60a8da572b0a60b6d33f4618c91c7b55c#body_text
is schema:about of	named entity 'HUMAN' named entity 'CORONAVIRUSES' named entity 'NEW' named entity 'HIGH' named entity 'CURRENTLY' named entity 'LOWER' named entity 'MOLECULAR' named entity 'VIRUSES' named entity 'CLINICAL' named entity 'PLASTICITY' named entity 'ANALYSIS' named entity 'DISTINCT' named entity 'BELGIUM' named entity 'ONE OF' named entity 'OUR' named entity 'CIRCULATING' named entity 'RESPONSIBLE' named entity 'END' named entity 'HIGH' named entity 'CHARACTERIZED' named entity 'CLUSTERS' named entity 'THESE' named entity 'SAMPLES' named entity 'STUDY' named entity 'RESPIRATORY INFECTIONS' named entity 'HUMAN' named entity 'ASSOCIATION' named entity 'OBJECTIVES' named entity 'SPECIMENS' named entity 'OC43' named entity 'GENES' named entity 'ITS' named entity 'ISOLATES' named entity 'GENOME' named entity 'OC43' named entity 'INTRA' named entity 'DETECTED' named entity 'AVAILABLE' covid:arg/616eb9a60a8da572b0a60b6d33f4618c91c7b55c named entity 'RECOMBINANT' named entity 'TO DETECT' named entity 'COLLECTED' named entity 'HONG' named entity 'ANALYSIS' named entity 'GENOTYPES' named entity 'SPECIFIC' named entity 'GENOMIC' named entity 'CIRCULATING' named entity 'FRANCE' named entity 'CORONAVIRUSES' named entity 'DIFFERENT' named entity 'LIKE' named entity '27S' named entity 'NORMANDY' named entity 'REVEALED' named entity 'NEW' named entity 'TEMPORAL' named entity 'COMPLETE' named entity 'USA' named entity 'COMPARED' named entity 'CLUSTER' named entity 'THIRTEEN' named entity 'DATA' named entity 'HCOV-OC43' named entity 'RECOMBINANT' named entity 'DESCRIPTION' named entity 'REVEALS' named entity 'DIVERSITY' named entity 'GENOTYPES' named entity 'CURRENT' named entity 'LED' named entity 'HUMAN CORONAVIRUS OC43' named entity 'IDENTIFICATION' named entity 'clinical samples' named entity 'genetically distinct' named entity 'recombinant'

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