About: Bordetella pertussis in infants hospitalized for acute respiratory symptoms remains a concern

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About: Bordetella pertussis in infants hospitalized for acute respiratory symptoms remains a concern Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bordetella pertussis in infants hospitalized for acute respiratory symptoms remains a concern
Creator	Bonci, Enea Carannante, Anna Ferrara, Marianna Midulla, Fabio Moretti, Corrado Nenna, Raffaella Nicolai, Ambra Papasso, Stefano Papoff, Paola Pierangeli, Alessandra Scagnolari, Carolina Schiavariello, Concetta Stefanelli, Paola
Source	Medline; PMC
abstract	BACKGROUND: Preliminary results suggest that pertussis infection might be considered in infants during a seasonal respiratory syncytial virus (RSV) outbreak. METHODS: In order to analyze clinical features and laboratory findings in infants with pertussis hospitalized for acute respiratory symptoms during a seasonal RSV outbreak, we conducted a retrospective single-center study on 19 infants with pertussis (6 boys; median age 72 days) and 19 matched controls (RSV-bronchiolitis), hospitalized from October 2008 to April 2010. B. pertussis and RSV were detected from nasopharyngeal washes with Real Time-PCR. RESULTS: Infants with pertussis were less often breastfeed than infants with RSV bronchiolitis (63.2% vs 89.5%; p <0.06). Clinically, significantly fewer infants with pertussis than controls had more episodes of whooping cough (63.2% vs 0.0%; p < 0.001) and also less frequently fever at admission (15.8% vs 68.4%; p <0.01), apnea (52.6% vs 10.5%; p <0.006), and cyanosis (52.6% vs 10.5%; p < 0.006). Infants with pertussis had more often no abnormal chest sounds on auscultation than infants with RSV bronchiolitis (0% vs 42,1%; p < 0.005). The absolute blood lymphocyte and eosinophil counts were higher in infants with B. pertussis than in controls with bronchiolitis (23886 ± 16945 vs 10725 ± 4126 cells/mm(3), p < 0.0001 and 13.653 ± 10.430 vs 4.730 ± 2.400 cells/mm(3), p < 0.001). The molecular analysis of 2 B. pertussis isolates for ptxA1, ptxP3, and prn2 genes showed the presence of gene variants. CONCLUSIONS: When infants are hospitalized for acute respiratory symptoms, physicians should suspect a pertussis infection, seek for specific clinical symptoms, investigate lymphocyte and eosinophil counts and thus diagnose infection early enough to allow treatment.
has issue date	2013-11-08(xsd:dateTime)
bibo:doi	10.1186/1471-2334-13-526
bibo:pmid	24209790
has license	cc-by
sha1sum (hex)	6086be90c6e06e3fcbef307a61c0563e029ee24d
schema:url	https://doi.org/10.1186/1471-2334-13-526
resource representing a document's title	Bordetella pertussis in infants hospitalized for acute respiratory symptoms remains a concern
has PubMed Central identifier	PMC4226035
has PubMed identifier	24209790
schema:publication	BMC Infect Dis
resource representing a document's body	covid:6086be90c6e06e3fcbef307a61c0563e029ee24d#body_text
is schema:about of	named entity 'CONCERN' named entity 'ACUTE' named entity 'BORDETELLA PERTUSSIS' covid:arg/6086be90c6e06e3fcbef307a61c0563e029ee24d named entity 'SEASONAL' named entity 'PERTUSSIS' named entity 'INFANTS' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'CONSIDERED' named entity 'BACKGROUND' named entity 'HOSPITALIZED' named entity 'INFANTS' named entity 'RESPIRATORY SYMPTOMS' named entity 'OUTBREAK' named entity 'SUGGEST' named entity 'INFECTION' named entity 'MIGHT BE' named entity 'PRELIMINARY RESULTS' named entity 'infection' named entity 'symptoms' named entity 'Preliminary results' named entity 'RSV' named entity 'cyanosis' named entity 'RSV' named entity 'tetanus' named entity 'protein' named entity 'pertussis' named entity 'fever' named entity 'pertussis' named entity 'MgSO' named entity 'DTaP' named entity 'co-morbidity' named entity 'bronchiolitis' named entity '3, 4' named entity 'pertussis' named entity 'whooping cough' named entity 'RT-PCR' named entity 'Belgium' named entity 'vaccine' named entity 'lymphocyte' named entity 'Pediatric' named entity 'respiratory symptoms' named entity 'pertactin' named entity 'pertussis toxin' named entity 'respiratory syncytial virus' named entity 'Tdap' named entity 'B. Pertussis' named entity 'Germany' named entity 'antibiotic therapy' named entity 'nucleotide sequences' named entity 'molecular sequence data' named entity 'bronchiolitis' named entity 'eosinophil' named entity 'bronchiolitis' named entity 'Germany' named entity 'macrolides' named entity 'B. pertussis' named entity 'B. pertussis' named entity 'allele' named entity 'arterial oxygen saturation' named entity 'pertussis' named entity 'B. pertussis' named entity 'booster doses' named entity 'B. pertussis' named entity 'platelet' named entity 'unimmunized' named entity 'Fisher test' named entity 'B. pertussis' named entity 'RSV'

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