About: Antiproliferative and apoptosis inducing effect of essential oil extracted from Cyrtomium fortumei (J.) Smith leaves

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About: Antiproliferative and apoptosis inducing effect of essential oil extracted from Cyrtomium fortumei (J.) Smith leaves Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiproliferative and apoptosis inducing effect of essential oil extracted from Cyrtomium fortumei (J.) Smith leaves
Creator	Zhao, Qi Xue, Wei Liu, Mingchuan Yang, Shengjie Yang, Song Zhao, Hongju
Source	Medline; PMC
abstract	Cyrtomium fortumei (J.) Smith is an endemic species in China, which has been proved to be an important Chinese herbal medicine. However, chemical composition and bioactivity of essential oil (EO) of C. fortumei (J.) Smith leaves remain unclear. In present study, we isolated EO from the plant by supercritical carbon dioxide extraction assay (SFE-CO(2)), and investigated on cancer cells MGC-803, MCF-7, BGC-823, Bcap-37, A375, and A549 in vitro by MTT assay. 26 compounds were identified by GC–MS analysis, and the EO showed significant antitumor activities against MGC-803, Bcap-37, and A549 cancer cell lines (IC(50) values ranging from 0.15 to 0.24 mg/mL), and the activities of its main component were also studied. Subsequent fluorescence staining and flow cytometry analysis indicated that the EO could induce apoptosis in MGC-803, Bcap-37, and A549 cell lines, and the apoptosis ratios reached 26.44 % after 48 h of treatment at 0.15 mg/mL in MGC-803 cells. Caspase 3 activity in MGC-803 cells was also determined when the cells treated with the oil, and the activity of caspase 3 enzyme was increased compared to the control. This study suggests that the EO isolated from C. fortumei (J.) Smith could inhibit the growth of human carcinoma cells, and it could induce apoptosis of cancer cells. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00044-014-1244-1) contains supplementary material, which is available to authorized users.
has issue date	2014-09-04(xsd:dateTime)
bibo:doi	10.1007/s00044-014-1244-1
bibo:pmid	32214767
has license	no-cc
sha1sum (hex)	605368f83e2636343ecc9e11c721c0aa8d3ea94c
schema:url	https://doi.org/10.1007/s00044-014-1244-1
resource representing a document's title	Antiproliferative and apoptosis inducing effect of essential oil extracted from Cyrtomium fortumei (J.) Smith leaves
has PubMed Central identifier	PMC7079878
has PubMed identifier	32214767
schema:publication	Med Chem Res
resource representing a document's body	covid:605368f83e2636343ecc9e11c721c0aa8d3ea94c#body_text
is schema:about of	named entity 'essential oil' named entity 'cells' named entity 'investigated' named entity 'assay' named entity 'extracted' named entity 'apoptosis' named entity 'ESSENTIAL OIL' named entity 'BGC-823' named entity 'CARCINOMA CELLS' named entity 'SMITH' named entity 'ISOLATED' named entity 'RATIOS' named entity 'CHINA' named entity 'INDICATED' named entity 'OIL' named entity 'A375' named entity 'CANCER CELL LINES' named entity 'MGC-803' named entity 'PRESENT' named entity 'IMPORTANT' named entity 'ACTIVITY' named entity 'INCREASED' named entity 'MCF-7' named entity 'COMPONENT' named entity 'HUMAN' named entity 'SMITH' named entity 'CASPASE 3' named entity 'CYRTOMIUM' named entity 'EXTRACTED' named entity 'LEAVES' named entity 'TREATED WITH' named entity 'ENZYME' named entity 'CANCER CELLS' named entity 'CONTROL' named entity 'IDENTIFIED BY' named entity 'CELLS' named entity 'INDUCING' named entity 'EFFECT' named entity 'APOPTOSIS' named entity 'ANTIPROLIFERATIVE' named entity 'ANTITUMOR' named entity 'COMPARED' named entity 'CHINESE HERBAL MEDICINE' named entity 'APOPTOSIS' named entity 'SUPERCRITICAL CARBON DIOXIDE' named entity 'EXTRACTION' named entity 'ACTIVITIES' named entity 'ENDEMIC SPECIES' named entity 'IN VITRO' named entity 'GC-MS' named entity 'A549 CELL' named entity 'CYRTOMIUM' named entity 'SUBSEQUENT' named entity 'UNCLEAR' named entity '0.15' named entity 'INDUCE' named entity 'BIOACTIVITY' named entity 'FLUORESCENCE STAINING' named entity 'DETERMINED' named entity 'GROWTH' named entity 'CHEMICAL COMPOSITION' named entity 'ANALYSIS' named entity 'TREATMENT' named entity 'BCAP' named entity '0.24' named entity 'MAIN' named entity 'LEAVES' named entity 'CELL LINES' named entity 'FLOW CYTOMETRY' named entity 'STUDY' named entity 'ITS' named entity 'SIGNIFICANT' named entity 'ESSENTIAL OIL' named entity 'ASSAY' named entity 'VALUES' named entity 'MG%'

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