About: Integrative Deep Sequencing of the Mouse Lung Transcriptome Reveals Differential Expression of Diverse Classes of Small RNAs in Response to Respiratory Virus Infection

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About: Integrative Deep Sequencing of the Mouse Lung Transcriptome Reveals Differential Expression of Diverse Classes of Small RNAs in Response to Respiratory Virus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Integrative Deep Sequencing of the Mouse Lung Transcriptome Reveals Differential Expression of Diverse Classes of Small RNAs in Response to Respiratory Virus Infection
Creator	Baric, Ralph Frieman, Matthew Gralinski, Lisa Kawaoka, Yoshihiro Peng, Xinxia Heise, Mark Proll, Sean Li, Chengjun Ferris, Martin Luo, Shujun Schroth, Gary Cullen, Bryan Katze, Michael Korth, Marcus Thomas, Matthew Tisoncik, Jennifer Tumpey, Terrence
Source	Medline; PMC
abstract	We previously reported widespread differential expression of long non-protein-coding RNAs (ncRNAs) in response to virus infection. Here, we expanded the study through small RNA transcriptome sequencing analysis of the host response to both severe acute respiratory syndrome coronavirus (SARS-CoV) and influenza virus infections across four founder mouse strains of the Collaborative Cross, a recombinant inbred mouse resource for mapping complex traits. We observed differential expression of over 200 small RNAs of diverse classes during infection. A majority of identified microRNAs (miRNAs) showed divergent changes in expression across mouse strains with respect to SARS-CoV and influenza virus infections and responded differently to a highly pathogenic reconstructed 1918 virus compared to a minimally pathogenic seasonal influenza virus isolate. Novel insights into miRNA expression changes, including the association with pathogenic outcomes and large differences between in vivo and in vitro experimental systems, were further elucidated by a survey of selected miRNAs across diverse virus infections. The small RNAs identified also included many non-miRNA small RNAs, such as small nucleolar RNAs (snoRNAs), in addition to nonannotated small RNAs. An integrative sequencing analysis of both small RNAs and long transcripts from the same samples showed that the results revealing differential expression of miRNAs during infection were largely due to transcriptional regulation and that the predicted miRNA-mRNA network could modulate global host responses to virus infection in a combinatorial fashion. These findings represent the first integrated sequencing analysis of the response of host small RNAs to virus infection and show that small RNAs are an integrated component of complex networks involved in regulating the host response to infection.
has issue date	2011-11-15(xsd:dateTime)
bibo:doi	10.1128/mbio.00198-11
bibo:pmid	22086488
has license	cc-by-nc-sa
sha1sum (hex)	602981d75e74595af0e2de9e046a9cc9e05a1c0e
schema:url	https://doi.org/10.1128/mbio.00198-11
resource representing a document's title	Integrative Deep Sequencing of the Mouse Lung Transcriptome Reveals Differential Expression of Diverse Classes of Small RNAs in Response to Respiratory Virus Infection
has PubMed Central identifier	PMC3221602
has PubMed identifier	22086488
schema:publication	mBio
resource representing a document's body	covid:602981d75e74595af0e2de9e046a9cc9e05a1c0e#body_text
is schema:about of	named entity 'INBRED' named entity 'STUDY' named entity 'RESPONSE TO VIRUS' named entity 'RECOMBINANT' named entity 'RNAS' named entity 'PREVIOUSLY' named entity 'FOUNDER' named entity 'PROTEIN-CODING' named entity 'MOUSE STRAINS' named entity 'COMPLEX TRAITS' named entity 'MOUSE' named entity 'NON-' named entity 'RESOURCE' named entity 'HOST RESPONSE' named entity 'WIDESPREAD' named entity 'RESPONSE TO' named entity 'SMALL' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity '200' named entity 'REPORTED' named entity 'DEEP SEQUENCING' named entity 'OBSERVED' named entity 'ACROSS' named entity 'LONG' named entity 'EXPANDED ' named entity 'REVEALS' named entity 'CLASSES' named entity 'DIFFERENTIAL EXPRESSION' named entity 'TRANSCRIPTOME' named entity 'RESPIRATORY VIRUS INFECTION' named entity 'RESPONSE TO' named entity 'SEQUENCING ANALYSIS' named entity 'COLLABORATIVE' named entity 'SMALL RNA' named entity 'CROSS' named entity 'MOUSE LUNG' named entity 'VIRUS INFECTION' named entity 'DIFFERENTIAL EXPRESSION' named entity 'RNAS' named entity 'DIVERSE' named entity 'INFECTIONS' named entity 'HERE' named entity 'INFLUENZA VIRUS' named entity 'SMALL' named entity 'TRANSCRIPTOME SEQUENCING' named entity 'MAPPING' named entity 'complex traits' named entity 'ncRNAs' named entity 'SARS-CoV' named entity 'Virus' named entity 'influenza virus' named entity 'mouse strains' named entity 'miR-155' named entity 'loci' named entity 'miRNA' named entity 'small RNA' named entity 'differentially expressed' named entity 'miRNAs' named entity 'small RNAs' named entity 'SARS-CoV' named entity 'H/ACA' named entity 'Small RNA' named entity 'severe acute respiratory syndrome coronavirus' named entity 'germ line cells' named entity 'SARS-CoV'

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