About: Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma
Creator	Pappas, Tressa Gern, James Gangnon, Ronald Evans, Michael Jackson, Daniel Lemanske, Robert Roberg, Kathy Singh, Anne Ky, Guilbert, Theresa Anderson, Elizabeth Burton, Ryan Danov, Zoran Madison, Lexington
topic	covid:6014bdbf564ac28219dadfc33ff5abad1bc25ee6#this
Source	Elsevier; Medline; PMC
abstract	Background Preschool rhinovirus (RV) wheezing illnesses predict an increased risk of childhood asthma; however, it is not clear how specific viral illnesses in early life relate to lung function later on in childhood. Objective To determine the relationship of virus-specific wheezing illnesses and lung function in a longitudinal cohort of children at risk for asthma. Methods Two hundred thirty-eight children were followed prospectively from birth to 8 years of age. Early life viral wheezing respiratory illnesses were assessed by using standard techniques, and lung function was assessed annually by using spirometry and impulse oscillometry. The relationships of these virus-specific wheezing illnesses and lung function were assessed by using mixed-effect linear regression. Results Children with RV wheezing illness demonstrated significantly decreased spirometry values, FEV1 (P = .001), FEV0.5 (P < .001), FEF25-75 (P < .001), and also had abnormal impulse oscillometry measures—more negative reactance at 5 Hz (P < .001)—compared with those who did not wheeze with RV. Children who wheezed with respiratory syncytial virus or other viral illnesses did not have any significant differences in spirometric or impulse oscillometry indices when compared with children who did not. Children diagnosed with asthma at ages 6 or 8 years had significantly decreased FEF25-75 (P = .05) compared with children without asthma. Conclusion Among outpatient viral wheezing illnesses in early childhood, those caused by RV infections are the most significant predictors of decreased lung function up to age 8 years in a high-risk birth cohort. Whether low lung function is a cause and/or effect of RV wheezing illnesses is yet to be determined.
has issue date	2011-09-30(xsd:dateTime)
bibo:doi	10.1016/j.jaci.2011.06.037
bibo:pmid	21878241
has license	els-covid
sha1sum (hex)	6014bdbf564ac28219dadfc33ff5abad1bc25ee6
schema:url	https://doi.org/10.1016/j.jaci.2011.06.037
resource representing a document's title	Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma
has PubMed Central identifier	PMC3233203
has PubMed identifier	21878241
schema:publication	Journal of Allergy and Clinical Immunology
resource representing a document's body	covid:6014bdbf564ac28219dadfc33ff5abad1bc25ee6#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/6014bdbf564ac28219dadfc33ff5abad1bc25ee6
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