About: Bacillus subtilis spores as adjuvants against avian influenza H9N2 induce antigen-specific antibody and T cell responses in White Leghorn chickens

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Bacillus subtilis spores as adjuvants against avian influenza H9N2 induce antigen-specific antibody and T cell responses in White Leghorn chickens Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bacillus subtilis spores as adjuvants against avian influenza H9N2 induce antigen-specific antibody and T cell responses in White Leghorn chickens
Creator	Kim, Hyungkuen Kim, Sung-Jo Park, Byung-Chul Shim, Byoung-Shik Yun, Cheol-Heui Park, Sung-Moo Han, Seung Lee, Ji Park, Tae Hwang, Eunmi Kye, Yoon-Chul Yoo, Sungsik
Source	PMC
abstract	Low-pathogenicity avian influenza H9N2 remains an endemic disease worldwide despite continuous vaccination, indicating the need for an improved vaccine strategy. Bacillus subtilis (B. subtilis), a gram-positive and endospore-forming bacterium, is a non-pathogenic species that has been used in probiotic formulations for both animals and humans. The objective of the present study was to elucidate the effect of B. subtilis spores as adjuvants in chickens administered inactivated avian influenza virus H9N2. Herein, the adjuvanticity of B. subtilis spores in chickens was demonstrated by enhancement of H9N2 virus-specific IgG responses. B. subtilis spores enhanced the proportion of B cells and the innate cell population in splenocytes from chickens administered both inactivated H9N2 and B. subtilis spores (Spore + H9N2). Furthermore, the H9N2 and spore administration induced significantly increased expression of the pro-inflammatory cytokines IL-1β and IL-6 compared to that in the H9N2 only group. Additionally, total splenocytes from chickens immunized with inactivated H9N2 in the presence or absence of B. subtilis spores were re-stimulated with inactivated H9N2. The subsequent results showed that the extent of antigen-specific CD4(+) and CD8(+) T cell proliferation was higher in the Spore + H9N2 group than in the group administered only H9N2. Taken together, these data demonstrate that B. subtilis spores, as adjuvants, enhance not only H9N2 virus-specific IgG but also CD4(+) and CD8(+) T cell responses, with an increase in pro-inflammatory cytokine production. This approach to vaccination with inactivated H9N2 together with a B. subtilis spore adjuvant in chickens produces a significant effect on antigen-specific antibody and T cell responses against avian influenza virus.
has issue date	2020-05-24(xsd:dateTime)
bibo:doi	10.1186/s13567-020-00788-8
has license	cc-by
sha1sum (hex)	5fc2ded5f550d77d7b2ad2c46c648da93daa09fc
schema:url	https://doi.org/10.1186/s13567-020-00788-8
resource representing a document's title	Bacillus subtilis spores as adjuvants against avian influenza H9N2 induce antigen-specific antibody and T cell responses in White Leghorn chickens
has PubMed Central identifier	PMC7245620
schema:publication	Vet Res
resource representing a document's body	covid:5fc2ded5f550d77d7b2ad2c46c648da93daa09fc#body_text
is schema:about of	named entity 'H9N2' named entity 'H9N2' named entity 'spore' named entity 'antibody' named entity 'H9N2' named entity 'Bacillus' named entity 'avian influenza' named entity 'B cells' named entity 'CD8' named entity 'Bacillus' named entity 'spores' named entity 'group' named entity 'responses' named entity 'virus-specific' named entity 'antibody' named entity 'adjuvants' named entity 'Spore' named entity 'B. subtilis' named entity 'B. subtilis' named entity 'splenocytes' named entity 'IgG' named entity 'spores' named entity 'H9N2' named entity 'B. subtilis' named entity 'pathogenicity' named entity 'B. subtilis' named entity 'spore' named entity 'pro-inflammatory cytokines' named entity 'CD4 +' named entity 'B. subtilis' named entity 'antigen' named entity 'avian influenza virus' named entity 'spores' named entity 'avian influenza' named entity 'adjuvants' named entity 'Bacillus subtilis' named entity 'antigen' named entity 'chickens' named entity 'Alexa Fluor' named entity 'B. subtilis' named entity 'GraphPad Prism' named entity 'IL-17' named entity 'Asia' named entity 'B. subtilis' named entity 'immunological memory' named entity 'CD8 +' named entity 'pro-inflammatory cytokines' named entity 'H9N2' named entity 'neutralizing antibody' named entity 'spores' named entity 'CT-3' named entity 'helper T cells' named entity 'chicken' named entity 'macrophage' named entity 'antibody' named entity 'IgG' named entity 'vaccine adjuvants' named entity 'innate immune cells' named entity 'mRNA expression' named entity 'CD4' named entity 'H9N2' named entity 'B. subtilis' named entity 'adjuvant' named entity 'single cells' named entity 'H9N2' named entity 'spores' named entity 'cDNA' named entity 'significant difference' named entity 'vaccine' named entity 'CD3' named entity 'innate immune cells' named entity 'pathogenicity'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software