About: Dengue Virus Infection Perturbs Lipid Homeostasis in Infected Mosquito Cells

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Dengue Virus Infection Perturbs Lipid Homeostasis in Infected Mosquito Cells
Creator	Perera, Rushika Adamec, Jiri Isaac, Giorgis Pasa-Tolic, Ljiljana Riley, Catherine Kuhn, Richard Metz, Thomas Weitz, Karl Hopf-Jannasch, Amber Moore, Ronald
source	PMC
abstract	Dengue virus causes ∼50–100 million infections per year and thus is considered one of the most aggressive arthropod-borne human pathogen worldwide. During its replication, dengue virus induces dramatic alterations in the intracellular membranes of infected cells. This phenomenon is observed both in human and vector-derived cells. Using high-resolution mass spectrometry of mosquito cells, we show that this membrane remodeling is directly linked to a unique lipid repertoire induced by dengue virus infection. Specifically, 15% of the metabolites detected were significantly different between DENV infected and uninfected cells while 85% of the metabolites detected were significantly different in isolated replication complex membranes. Furthermore, we demonstrate that intracellular lipid redistribution induced by the inhibition of fatty acid synthase, the rate-limiting enzyme in lipid biosynthesis, is sufficient for cell survival but is inhibitory to dengue virus replication. Lipids that have the capacity to destabilize and change the curvature of membranes as well as lipids that change the permeability of membranes are enriched in dengue virus infected cells. Several sphingolipids and other bioactive signaling molecules that are involved in controlling membrane fusion, fission, and trafficking as well as molecules that influence cytoskeletal reorganization are also up regulated during dengue infection. These observations shed light on the emerging role of lipids in shaping the membrane and protein environments during viral infections and suggest membrane-organizing principles that may influence virus-induced intracellular membrane architecture.
has issue date	2012-03-22(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1002584
bibo:pmid	22457619
has license	cc-by
sha1sum (hex)	5fa62370245d4ad73220d6f42f8cb66064627aaa
schema:url	https://doi.org/10.1371/journal.ppat.1002584
resource representing a document's title	Dengue Virus Infection Perturbs Lipid Homeostasis in Infected Mosquito Cells
has PubMed Central identifier	PMC3310792
has PubMed identifier	22457619
schema:publication	PLoS Pathog
resource representing a document's body	covid:5fa62370245d4ad73220d6f42f8cb66064627aaa#body_text
is schema:about of	named entity 'CELLS' named entity 'LIPID HOMEOSTASIS' named entity 'membranes' named entity 'fission' named entity 'intracellular' named entity 'involved' named entity 'dengue' named entity 'intracellular membranes' named entity 'observed' named entity 'enzyme' named entity 'TRAFFICKING' named entity 'INFECTIONS' named entity 'ENZYME' named entity 'USING' named entity 'INHIBITION' named entity 'VIRUS' named entity 'DENGUE VIRUS' named entity 'OBSERVATIONS' named entity 'ONE OF' named entity 'INFECTED' named entity 'HAVE' named entity 'CHANGE' named entity 'ISOLATED' named entity 'PROTEIN ' named entity 'HUMAN' named entity 'FATTY ACID SYNTHASE' named entity 'REPLICATION' named entity 'UNINFECTED' named entity 'LIGHT' named entity 'INFLUENCE' named entity 'DIFFERENT' named entity 'REGULATED' named entity 'INTRACELLULAR MEMBRANES' named entity 'CAPACITY' named entity 'LIPID' named entity 'FISSION' named entity 'VIRUS REPLICATION' named entity 'REMODELING' named entity 'DENGUE INFECTION' named entity 'INFECTED MOSQUITO' named entity 'SUGGEST' named entity 'INHIBITORY' named entity 'CURVATURE' named entity 'VECTOR' named entity 'MOLECULES' named entity 'ENVIRONMENTS' named entity 'REDISTRIBUTION' named entity 'CAUSES' named entity 'MOSQUITO' named entity 'CELL SURVIVAL' named entity 'HIGH-RESOLUTION MASS SPECTROMETRY' named entity 'REPERTOIRE' named entity 'ALTERATIONS' named entity 'INTRACELLULAR' named entity 'AGGRESSIVE' named entity 'ARCHITECTURE' named entity 'PER YEAR' named entity 'SIGNALING MOLECULES' named entity 'CELLS' named entity 'THESE' named entity 'SUFFICIENT' named entity 'LIPID BIOSYNTHESIS' named entity 'SPHINGOLIPIDS' named entity 'DERIVED' named entity 'INVOLVED' named entity 'BUT' named entity 'MEMBRANES' named entity 'CYTOSKELETAL REORGANIZATION' named entity 'MEMBRANE' named entity 'LIPIDS' named entity 'CONTROLLING' named entity 'PERMEABILITY'

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