About: Broad-spectrum neutralization of avian influenza viruses by sialylated human milk oligosaccharides: in vivo assessment of 3′-sialyllactose against H9N2 in chickens

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About: Broad-spectrum neutralization of avian influenza viruses by sialylated human milk oligosaccharides: in vivo assessment of 3′-sialyllactose against H9N2 in chickens Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Broad-spectrum neutralization of avian influenza viruses by sialylated human milk oligosaccharides: in vivo assessment of 3′-sialyllactose against H9N2 in chickens
Creator	Song, Jaeyoung Woo, Jinsuk Kim, Joon Cheong, Kwang Jang, Sang Kim, Dae Oh, Jin Pandey, Ramesh Sohng, Jae
Source	Medline; PMC
abstract	Two sialylated human milk oligosaccharides (SHMOs) 3′-sialyllactose (3′-SL) and 6′-sialyllactose (6′-SL) were accessed for their possible antiviral activity against six different subtypes of thirteen avian influenza (AI) viruses in vitro. 3′-SL exhibited promising antiviral activity against almost all subtypes of tested AI viruses in hemagglutination inhibition assay, whereas 6′-SL showed activity against few selected H1N1, H1N2, and H3N2 subtype strains. 3′-SL has minimum inhibitory concentration values of 15.62 mM or less in more than half of the viruses examined. 3′-SL also showed effective inactivation of H9N2 Korea isolate (A/Chicken/Korea/MS96/1996) at 12.5 mM concentration in Madin Darby Canine Kidney (MDCK) cell line. Thus, 3′-SL was further studied for in vivo study against H9N2 virus in pathogen free chicken experiment models. In vivo study exhibited improved clinical symptoms on H9N2 infected chickens when treated with 3′-SL. Moreover, treating chickens with 3′-SL resulted in complete elimination of H9N2 viruses within 24 h of virus infection (0.8 HAU of H9N2). Indirect ELISA assay confirmed complete wash-out of H9N2 viruses from the colon after neutralization by 3′-SL without entering the blood stream. These in vivo results open up possible applications of 3′-SL for the prevention of AI virus infections in birds by a simple cleansing mechanism.
has issue date	2018-02-07(xsd:dateTime)
bibo:doi	10.1038/s41598-018-20955-4
bibo:pmid	29416087
has license	cc-by
sha1sum (hex)	5f81496a02673e6967f71dfbc8d4112a29d3d1b8
schema:url	https://doi.org/10.1038/s41598-018-20955-4
resource representing a document's title	Broad-spectrum neutralization of avian influenza viruses by sialylated human milk oligosaccharides: in vivo assessment of 3′-sialyllactose against H9N2 in chickens
has PubMed Central identifier	PMC5803236
has PubMed identifier	29416087
schema:publication	Sci Rep
resource representing a document's body	covid:5f81496a02673e6967f71dfbc8d4112a29d3d1b8#body_text
is schema:about of	named entity 'NEUTRALIZATION' named entity 'VIRUS' named entity 'CHICKENS' named entity 'H3N2 SUBTYPE' named entity 'OPEN' named entity 'MECHANISM' named entity 'H1N1' named entity 'SPECTRUM' named entity 'POSSIBLE' named entity 'PATHOGEN' named entity 'RESULTS' named entity 'WASH' named entity 'THESE' named entity 'SIMPLE' named entity 'INDIRECT' named entity '28A' named entity 'IN VIVO STUDY' named entity '80%' named entity 'INFECTED' named entity 'IMPROVED' named entity 'MINIMUM INHIBITORY CONCENTRATION' named entity 'VIRUS INFECTION' named entity 'IN VIVO' named entity 'ASSESSMENT' named entity 'HUMAN MILK' named entity 'AVIAN INFLUENZA' named entity 'INFLUENZA VIRUSES' named entity 'COMPLETE' named entity 'VALUES' named entity '80%' named entity 'BIRDS' named entity 'H1N2' named entity 'INFECTIONS' named entity 'CHICKEN' named entity 'STRAINS' named entity 'EXAMINED' named entity 'EXPERIMENT' named entity 'MORE THAN' named entity 'FREE' named entity 'HAU' named entity '12.5' named entity 'APPLICATIONS' named entity 'CANINE' named entity 'COLON' named entity 'KIDNEY' named entity 'KOREA' named entity 'ELIMINATION' named entity 'CLEANSING' named entity 'ISOLATE' named entity 'SELECTED' named entity 'VIRUSES' named entity 'OLIGOSACCHARIDES' named entity 'H9N2 VIRUS' named entity 'TREATED WITH' named entity 'CONCENTRATION' named entity 'EFFECTIVE' named entity 'CONFIRMED' named entity 'CHICKENS' named entity 'PREVENTION OF' named entity '5 MM' named entity 'IN VIVO' named entity 'BLOOD' named entity 'HALF' named entity 'CLINICAL SYMPTOMS' named entity 'ELISA ASSAY' named entity 'TREATING' named entity 'BROAD' named entity 'CELL LINE' named entity 'INACTIVATION' named entity 'STREAM' named entity 'MODELS' covid:arg/5f81496a02673e6967f71dfbc8d4112a29d3d1b8 named entity 'pathogen'

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