About: Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease 2019

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About: Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease 2019 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease 2019
Creator	Liu, Ying Gu, Wei Li, Jing-Jing Kan, Xiao-Hua Qi, Jian-Wei Shi, Qian-Kun Sun, Jia-Kui Yuan, Shou-Tao Zhang, Wen-Hao Zou, Lei Dai, Lian Xu, Hong-Yang Yu, Wen-Kui
Source	Medline; PMC
abstract	The aim of this study was to investigate the correlations between serum calcium and clinical outcomes in patients with coronavirus disease 2019 (COVID-19). In this retrospective study, serum calcium levels, hormone levels and clinical laboratory parameters on admission were recorded. The clinical outcome variables were also recorded. From February 10 to February 28, 2020, 241 patients were enrolled. Of these patients, 180 (74.7%) had hypocalcemia on admission. The median serum calcium levels were 2.12 (IQR, 2.04-2.20) mmol/L, median parathyroid hormone (PTH) levels were 55.27 (IQR, 42.73-73.15) pg/mL, and median 25-hydroxy-vitamin D (VD) levels were 10.20 (IQR, 8.20-12.65) ng/mL. The serum calcium levels were significantly positively correlated with VD levels (P =0.004) but negatively correlated with PTH levels (P =0.048). Patients with lower serum calcium levels (especially ≤2.0 mmol/L) had worse clinical parameters, higher incidences of organ injury and septic shock, and higher 28-day mortality. The areas under the receiver operating characteristic curves of multiple organ dysfunction syndrome, septic shock, and 28-day mortality were 0.923 (P <0.001), 0.905 (P =0.001), and 0.929 (P <0.001), respectively. In conclusion, serum calcium was associated with the clinical severity and prognosis of patients with COVID-19. Hypocalcemia may be associated with imbalanced VD and PTH levels.
has issue date	2020-06-25(xsd:dateTime)
bibo:doi	10.18632/aging.103526
bibo:pmid	32589164
has license	cc-by
sha1sum (hex)	5f7b12cdfd95ac8e088c98fedc2041c6c7736348
schema:url	https://doi.org/10.18632/aging.103526
resource representing a document's title	Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease 2019
has PubMed Central identifier	PMC7343468
has PubMed identifier	32589164
schema:publication	Aging (Albany NY)
resource representing a document's body	covid:5f7b12cdfd95ac8e088c98fedc2041c6c7736348#body_text
is schema:about of	named entity 'COVID-19' named entity 'retrospective study' named entity 'PTH' named entity 'serum calcium' named entity 'IQR' named entity 'injury' named entity 'CALCIUM LEVELS' named entity 'MULTIPLE ORGAN DYSFUNCTION SYNDROME' named entity '28P' named entity 'OPERATING' named entity 'COVID-19' named entity 'CORRELATIONS' named entity 'RETROSPECTIVE STUDY' named entity 'FEBRUARY' named entity 'WORSE' named entity 'MAY BE' named entity 'CLINICAL LABORATORY' named entity 'LEVELS' named entity 'septic shock' named entity 'levels' named entity 'clinical laboratory' named entity 'Hypocalcemia' named entity 'IQR' named entity 'variables' named entity 'patients' named entity 'parathyroid hormone' named entity 'PTH' named entity 'positively correlated' named entity 'hypocalcemia' named entity 'serum calcium' named entity 'septic shock' named entity 'receiver operating characteristic' named entity 'septic shock' named entity 'mmol/L' named entity 'negatively correlated' named entity 'clinical laboratory' named entity 'prognosis' named entity 'Fisher's exact test' named entity 'Mann-Whitney U test' named entity 'retrospective study' named entity 'hypocalcemia' named entity 'nasal cannula' named entity 'diagnostic criteria' named entity 'serum calcium' named entity 'hypocalcemia' named entity 'septic shock' named entity 'mmol/L' named entity 'hypocalcemia' named entity 'serum levels' named entity 'AST' named entity 'critically ill patients' named entity 'ROC' named entity 'MODS' named entity 'clinical characteristics' named entity 'hormones' named entity 'serum calcium' named entity 'D-dimer' named entity 'continuous renal replacement therapy' named entity 'hypocalcemia' named entity 'septic shock' named entity 'median age' named entity 'COVID' named entity 'Huazhong University of Science and Technology' named entity 'COVID' named entity 'prognosis' named entity 'mmol/L' named entity 'mmol/L' named entity 'parathyroid hormone' named entity 'hypocalcemia'

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