About: Association Between Hypoxemia and Mortality in Patients With COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association Between Hypoxemia and Mortality in Patients With COVID-19
Creator	Gao, Wei Li, Guangxi An, Guang Covassin, Naima Fan, Zhengyang Kara, Tomas Singh, ; Singh, Fan Singh, Prachi Somers, Virend Vk, Somers Xie, Jiang
Source	Elsevier; Medline; PMC
abstract	Abstract Objective To identify markers associated with in-hospital death in patients with Coronavirus Disease 2019 (COVID-19) associated pneumonia. Patients and Methods Retrospective, cohort study of 140 patients with moderate-to-critical COVID-19 associated pneumonia requiring oxygen supplementation admitted from January 28th, 2020 to February 28th, 2020, and followed up through March, 13th 2020 in Union Hospital, Wuhan, China. Oxygen saturation (SpO2) and other measures were tested as predictors of in-hospital mortality in survival analysis. Results Of 140 patients with COVID-19 associated pneumonia, 51.4% were men, with a median age of 60 years. Patients with SpO2 ≤90% were older, more likely to be men, to have hypertension and to present with dyspnea than those with SpO2 >90%. Overall, 36 (25.7%) patients died during hospitalization after a median 14-day follow-up. Higher post-oxygen supplementation SpO2 levels were associated with reduced mortality independently of age and sex (hazard ratio per 1-unit SpO2 0.93, 95% confidence interval, 0.91-0.95, P < .001). SpO2 cutoff of 90.5% yielded 84.6% sensitivity and 97.2% specificity for prediction of survival. Dyspnea was also independently associated with death in multivariable analysis (hazard ratio 2.60; 95% confidence interval 1.24-5.43, P = .01). Conclusions In this cohort of COVID-19 patients, hypoxemia was independently associated with in-hospital mortality. These results may help guide clinical management of severe COVID-19 patients, particularly in settings requiring strategic allocation of limited critical care resources.
has issue date	2020-04-11(xsd:dateTime)
bibo:doi	10.1016/j.mayocp.2020.04.006
bibo:pmid	32376101
has license	els-covid
sha1sum (hex)	5f55a576b851f033f2ea5ac413d3b3d64369ffb1
schema:url	https://doi.org/10.1016/j.mayocp.2020.04.006
resource representing a document's title	Association Between Hypoxemia and Mortality in Patients With COVID-19
has PubMed Central identifier	PMC7151468
has PubMed identifier	32376101
schema:publication	Mayo Clin Proc
resource representing a document's body	covid:5f55a576b851f033f2ea5ac413d3b3d64369ffb1#body_text
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