About: Transmission heterogeneities, kinetics, and controllability of SARS-CoV-2

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About: Transmission heterogeneities, kinetics, and controllability of SARS-CoV-2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Transmission heterogeneities, kinetics, and controllability of SARS-CoV-2
Creator	Wang, Wei Wang, Yan Viboud, Cécile Zhan, Zhifei Yu, Hongjie Vespignani, Alessandro Ajelli, Marco Litvinova, Maria Zhao, Shanlu Chen, Xinghui Luo, Kaiwei Huang, Yiwei Liu, Ziyan Ren, Lingshuang Sun, Qianlai
source	MedRxiv; Medline
abstract	A long-standing question in infectious disease dynamics is the role of transmission heterogeneities, particularly those driven by demography, behavior and interventions. Here we characterize transmission risk between 1,178 SARS-CoV-2 infected individuals and their 15,648 close contacts based on detailed contact tracing data from Hunan, China. We find that 80% of secondary transmissions can be traced back to 14% of SARS-CoV-2 infections, indicating substantial transmission heterogeneities. Regression analysis suggests a marked gradient of transmission risk scales positively with the duration of exposure and the closeness of social interactions, after adjusted for demographic and clinical factors. Population-level physical distancing measures confine transmission to families and households; while case isolation and contact quarantine reduce transmission in all settings. Adjusted for interventions, the reconstructed infectiousness profile of a typical SARS-CoV-2 infection peaks just before symptom presentation, with ~50% of transmission occurring in the pre-symptomatic phase. Modelling results indicate that achieving SARS-CoV-2 control would require the synergistic efforts of case isolation, contact quarantine, and population-level physical distancing measures, owing to the particular transmission kinetics of this virus.
has issue date	2020-08-13(xsd:dateTime)
bibo:doi	10.1101/2020.08.09.20171132
bibo:pmid	32817975
has license	medrxiv
sha1sum (hex)	5ec3a6d38cf3ecf0b59898945b3233f0a3715403
schema:url	https://doi.org/10.1101/2020.08.09.20171132
resource representing a document's title	Transmission heterogeneities, kinetics, and controllability of SARS-CoV-2
has PubMed identifier	32817975
schema:publication	medRxiv : the preprint server for health sciences
resource representing a document's body	covid:5ec3a6d38cf3ecf0b59898945b3233f0a3715403#body_text
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