About: COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans

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About: COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans
Creator	Devaux, Christian Frutos, Roger Chen, Tianmu Serra-Cobo, Jordi
Source	Elsevier; Medline; PMC
abstract	The emergence of COVID-19 has triggered many works aiming at identifying the animal intermediate potentially involved in the transmission of SARS-CoV-2 to humans. The presence of SARS-CoV-2-related viruses in Malayan pangolins, in silico analysis of the ACE2 receptor polymorphism and sequence similarities between the Receptor Binding Domain (RBD) of the spike proteins of pangolin and human Sarbecoviruses led to the proposal of pangolin as intermediary. However, the binding affinity of the pangolin ACE2 receptor for SARS-CoV-2 RBD was later on reported to be low. Here, we provide evidence that the pangolin is not the intermediate animal at the origin of the human pandemic. Moreover, data available do not fit with the spillover model currently proposed for zoonotic emergence which is thus unlikely to account for this outbreak. We propose a different model to explain how SARS-CoV-2 related coronaviruses could have circulated in different species, including humans, before the emergence of COVID-19.
has issue date	2020-08-05(xsd:dateTime)
bibo:doi	10.1016/j.meegid.2020.104493
bibo:pmid	32768565
has license	no-cc
sha1sum (hex)	5eba7a2b5eeb4ad0a33a1d9b8df07ea805fd9acf
schema:url	https://doi.org/10.1016/j.meegid.2020.104493
resource representing a document's title	COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans
has PubMed Central identifier	PMC7405773
has PubMed identifier	32768565
schema:publication	Infect Genet Evol
resource representing a document's body	covid:5eba7a2b5eeb4ad0a33a1d9b8df07ea805fd9acf#body_text
is schema:about of	named entity 'COVID-19' named entity 'HUMANS' named entity 'INTERMEDIATE' named entity 'RECEPTOR' named entity 'TRIGGERED' named entity 'POLYMORPHISM' named entity 'PRESENCE OF' named entity 'origin' named entity 'animal' named entity 'pangolin' named entity 'SARS-CoV-2' named entity 'sequence similarities' named entity 'SARS-CoV-2' named entity 'pangolin' named entity 'pangolin' named entity 'ACE2 receptor' named entity 'ACE2 receptor' named entity 'spike protein' named entity 'virus' named entity 'receptor' named entity 'epizootic' named entity 'pangolin' named entity 'coronaviruses' named entity 'epidemic' named entity 'Sarbecovirus' named entity 'genome' named entity 'protein' named entity 'virus' named entity 'Zika' named entity 'ACE2' named entity 'bat' named entity 'genomic analysis' named entity 'COVID' named entity 'RBD' named entity 'zoonotic' named entity 'feces' named entity 'spike protein' named entity 'zoonotic' named entity 'WHO' named entity 'epidemic' named entity 'SARS-CoV-2' named entity 'wet markets' named entity 'chikungunya' named entity 'receptor' named entity 'pangolins' named entity 'Senio' named entity 'maximum likelihood' named entity 'SARS-CoV-2' named entity 'adaptive evolution' named entity 'pangolin' named entity 'Stawiski' named entity 'RBD' named entity 'pangolin' named entity 'intermediate host' named entity 'ACE2' named entity 'RBD' named entity 'Sarbecovirus' named entity 'immune surveillance' named entity 'SARS epidemic' named entity 'cell surface' named entity 'spike protein' named entity 'bat' named entity 'feces' named entity 'variable region' named entity 'bat' named entity 'RdRp' named entity 'bat' named entity 'virus' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'recombination' named entity 'RdRp' named entity 'guano' named entity 'binding affinity' named entity 'evolutionary process' named entity 'human population' named entity 'viruses' named entity 'SARS-CoV-2'

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