About: Toll-Like Receptor Responses to Peste des petits ruminants Virus in Goats and Water Buffalo

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Toll-Like Receptor Responses to Peste des petits ruminants Virus in Goats and Water Buffalo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Toll-Like Receptor Responses to Peste des petits ruminants Virus in Goats and Water Buffalo
Creator	Parida, Satya Biswas, Moanaro Dhanasekaran, Sakthivel Raja, Angamuthu Subbiah, Elankumaran Dhinakar, Gopal Kataria, Ranjit Ramya, R Tirumurugaan, Krishnaswamy Vignesh, Ambothi
Source	PMC
abstract	Ovine rinderpest or goat plague is an economically important and contagious viral disease of sheep and goats, caused by the Peste des petits ruminants virus (PPRV). Differences in susceptibility to goat plague among different breeds and water buffalo exist. The host innate immune system discriminates between pathogen associated molecular patterns and self antigens through surveillance receptors known as Toll like receptors (TLR). We investigated the role of TLR and cytokines in differential susceptibility of goat breeds and water buffalo to PPRV. We examined the replication of PPRV in peripheral blood mononuclear cells (PBMC) of Indian domestic goats and water buffalo and demonstrated that the levels of TLR3 and TLR7 and downstream signalling molecules correlation with susceptibility vs resistance. Naturally susceptible goat breeds, Barbari and Tellichery, had dampened innate immune responses to PPRV and increased viral loads with lower basal expression levels of TLR 3/7. Upon stimulation of PBMC with synthetic TLR3 and TLR7 agonists or PPRV, the levels of proinflammatory cytokines were found to be significantly higher while immunosuppressive interleukin (IL) 10 levels were lower in PPRV resistant Kanni and Salem Black breeds and water buffalo at transcriptional level, correlating with reduced viralloads in infected PBMC. Water buffalo produced higher levels of interferon (IFN) α in comparison with goats at transcriptional and translational levels. Pre-treatment of Vero cells with human IFNα resulted in reduction of PPRV replication, confirming the role of IFNα in limiting PPRV replication. Treatment with IRS66, a TLR7 antagonist, resulted in the reduction of IFNα levels, with increased PPRV replication confirming the role of TLR7. Single nucleotide polymorphism analysis of TLR7 of these goat breeds did not show any marked nucleotide differences that might account for susceptibility vs resistance to PPRV. Analyzing other host genetic factors might provide further insights on susceptibility to PPRV and genetic polymorphisms in the host.
has issue date	2014-11-04(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0111609
bibo:pmid	25369126
has license	cc-by
sha1sum (hex)	5eba29203084de16f501b71b64873f5c96ce55f2
schema:url	https://doi.org/10.1371/journal.pone.0111609
resource representing a document's title	Toll-Like Receptor Responses to Peste des petits ruminants Virus in Goats and Water Buffalo
has PubMed Central identifier	PMC4219731
has PubMed identifier	25369126
schema:publication	PLoS One
resource representing a document's body	covid:5eba29203084de16f501b71b64873f5c96ce55f2#body_text
is schema:about of	named entity 'WATER BUFFALO' named entity 'immunosuppressive' named entity 'plague' named entity 'Naturally' named entity 'goat' named entity 'goat' named entity 'Barbari' named entity 'proinflammatory cytokines' named entity 'water buffalo' named entity 'goats' named entity 'Indian' named entity 'goat' named entity 'Treatment' named entity 'Toll' named entity 'translational' named entity 'goat' named entity 'breeds' named entity 'stimulation' named entity 'levels' named entity 'FOUND' named entity 'INFECTED' named entity 'REDUCED' named entity 'POLYMORPHISMS' named entity 'PRE' named entity 'LEVEL' named entity 'CAUSED BY' named entity 'DEMONSTRATED' named entity 'COMPARISON' named entity 'PBMC' named entity 'PESTE DES PETITS RUMINANTS VIRUS' named entity 'MARKED' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'SUSCEPTIBILITY' named entity 'TLR' named entity 'SUSCEPTIBLE' named entity 'VIRAL DISEASE' named entity 'RESISTANT' named entity 'VIRAL' named entity 'MOLECULAR' named entity 'GENETIC FACTORS' named entity 'BREEDS' named entity 'LIMITING' named entity 'REPLICATION' named entity 'VERO CELLS' named entity '2F7' named entity 'ANTAGONIST' named entity 'INTERFERON ' named entity 'CORRELATION' named entity 'INSIGHTS' named entity 'HIGHER' named entity 'IFNA' named entity 'EXAMINED' named entity 'INDIAN' named entity 'KNOWN' named entity 'OVINE RINDERPEST' named entity 'EXIST' named entity 'PROINFLAMMATORY CYTOKINES' named entity 'REDUCTION' named entity 'SINGLE NUCLEOTIDE POLYMORPHISM ANALYSIS' named entity 'RESISTANCE TO' named entity 'TOLL LIKE RECEPTORS' named entity 'GOATS' named entity 'RECEPTORS' named entity 'PESTE DES PETITS RUMINANTS VIRUS' named entity 'DIFFERENT' named entity 'ECONOMICALLY IMPORTANT' named entity 'TREATMENT' named entity 'CONFIRMING' named entity 'INTERLEUKIN ' named entity 'NUCLEOTIDE' named entity 'DOMESTIC' named entity 'SYNTHETIC'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software