About: Design and Validation with Influenza A Virus of an Aerosol Transmission Chamber for Ferrets

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Design and Validation with Influenza A Virus of an Aerosol Transmission Chamber for Ferrets
Creator	Duchaine, Caroline Boivin, Guy Hamelin, Marie-Ève Rhéaume, Chantal Turgeon, Nathalie Carbonneau, Julie Girard, Matthieu Verreault, Daniel Checkmahomed, Liva Lévesque, Ariane
topic	covid:5eb20deb48c231973cf0a796ca1c6898cbf2d07d#this
Source	Medline; PMC
abstract	Background: The importance of aerosols in the spread of viruses like influenza is still a subject of debate. Indeed, most viruses can also be transmitted through direct contact and droplets. Therefore, the importance of the airborne route in a clinical context is difficult to determine. The aim of this study was to design a chamber system to study the airborne transmission of viruses between ferrets. Methods: A system composed of three chambers connected in series, each one housing one ferret and preventing direct contact, was designed. The chambers were designed to house the ferrets for several days and to study the transmission of viruses from an infected (index) ferret to two naïve ferrets via aerosols and droplets or aerosols only. A particle separator was designed that can be used to modulate the size of the particles traveling between the chambers. The chamber system was validated using standard dust as well as with ferrets infected with influenza A virus. Conclusions: The 50% efficiency cut-off of the separator could be modulated between a 5-µm and an 8-µm aerodynamic diameter. In the described setup, influenza A virus was transmitted through the aerosol route in two out of three experiments, and through aerosols and droplets in all three experiments.
has issue date	2019-02-19(xsd:dateTime)
bibo:doi	10.3390/ijerph16040609
bibo:pmid	30791478
has license	cc-by
sha1sum (hex)	5eb20deb48c231973cf0a796ca1c6898cbf2d07d
schema:url	https://doi.org/10.3390/ijerph16040609
resource representing a document's title	Design and Validation with Influenza A Virus of an Aerosol Transmission Chamber for Ferrets
has PubMed Central identifier	PMC6406687
has PubMed identifier	30791478
schema:publication	Int J Environ Res Public Health
resource representing a document's body	covid:5eb20deb48c231973cf0a796ca1c6898cbf2d07d#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/5eb20deb48c231973cf0a796ca1c6898cbf2d07d
is schema:about of	named entity 'INFLUENZA A VIRUS' named entity 'droplets' named entity 'determine' named entity 'aim' named entity 'efficiency' named entity 'Indeed' named entity 'chamber' named entity 'experiments' named entity 'modulate' named entity 'DIFFICULT' named entity 'AIM' named entity 'SEVERAL DAYS' named entity 'PREVENTING' named entity 'EFFICIENCY' named entity 'SERIES' named entity 'TRAVELING' named entity 'CLINICAL CONTEXT' named entity 'HOUSING' named entity 'BACKGROUND' named entity 'STANDARD' named entity 'VIRUSES' named entity 'INFECTED' named entity '50%' named entity 'SETUP' named entity 'AIRBORNE TRANSMISSION' named entity 'MODULATED' named entity 'TRANSMISSION' named entity 'CUT' named entity 'LIKE' named entity 'AEROSOLS' named entity 'ROUTE' named entity 'VALIDATION' named entity 'DIRECT' named entity 'INFLUENZA A VIRUS' named entity 'HOUSE' named entity 'SUBJECT' named entity 'VALIDATED' named entity 'STUDY' named entity 'CONCLUSIONS' named entity 'CHAMBERS' named entity 'FERRETS' named entity 'CHAMBER' named entity 'DESIGN' named entity 'AEROSOL' named entity 'CHAMBER' named entity 'SIZE' named entity 'MODULATE' named entity 'DESCRIBED' named entity 'TRANSMITTED' named entity 'SYSTEM' named entity 'PARTICLE' named entity 'FERRET' named entity 'AIRBORNE' named entity 'USED' named entity 'COMPOSED OF' named entity 'DUST' named entity 'FERRETS' named entity 'CONTACT' named entity 'DEBATE' named entity 'TRANSMISSION' named entity 'INFLUENZA' named entity 'DESIGN' named entity 'AEROSOL' named entity 'DETERMINE' named entity 'METHODS' named entity 'SPREAD' named entity 'COULD BE' named entity 'EXPERIMENTS' named entity 'DIAMETER' named entity 'SEPARATOR'

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