About: Anti‐bacterial IgE in the antibody responses of house dust mite allergic children convalescent from asthma exacerbation

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About: Anti‐bacterial IgE in the antibody responses of house dust mite allergic children convalescent from asthma exacerbation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Anti‐bacterial IgE in the antibody responses of house dust mite allergic children convalescent from asthma exacerbation
Creator	Zhang, G Bizzintino, J Goldblatt, J Lee, W-M Pearce, L Thomas, W Laing, I Martin, A Geelhoed, G Hales, B Hales, J Hayden, C Khoo, S-K Lesouëf, P Mcminn, P Rueter, K
Source	Medline; PMC
abstract	Background Atopic sensitization to the house dust mite (HDM) is associated with altered antibody responses to the nasopharyngeal colonizing bacterium Haemophilus influenzae and children admitted to the emergency department for asthma exacerbation have reduced IgG responses to HDM allergens. Objective To investigate anti‐bacterial and anti‐allergen antibody responses during convalescence from asthma exacerbation and differences found in exacerbations associated with and without viral infection. Results IgE antibodies to the P6 bacterial antigen increased in 60% of sera during convalescence and for many children achieved titres as high as IgE titres to allergens. In contrast IgE anti‐HDM titres declined during convalescence. The anti‐bacterial IgE titres were the same in subjects with and without virus infection while the anti‐HDM IgE declined more rapidly in virus‐infected subjects. IgG titres to the major HDM allergens showed no consistent increase and the overall IgG anti‐HDM titres even declined in subjects without a virus infection. Anti‐bacterial IgG antibodies in contrast to IgE did not change. Patients with frequent episodic or persistent asthma had similar IgE anti‐bacterial titres to patients with infrequent asthma during the acute phase, although they had reduced IgG titres to both the bacteria and the HDM. Conclusions During the period following an acute exacerbation of asthma there was a marked and specific increase in anti‐bacterial IgE compared with a reduced IgE response to HDM. This provides further support for the concept of T‐helper type 2 responses to bacterial antigens playing a role in asthma pathogenesis.
has issue date	2009-04-17(xsd:dateTime)
bibo:doi	10.1111/j.1365-2222.2009.03252.x
bibo:pmid	19400897
has license	no-cc
sha1sum (hex)	5ea11faeeb6298b0c25bd67e921154aec2197964
schema:url	https://doi.org/10.1111/j.1365-2222.2009.03252.x
resource representing a document's title	Anti‐bacterial IgE in the antibody responses of house dust mite allergic children convalescent from asthma exacerbation
has PubMed Central identifier	PMC7164829
has PubMed identifier	19400897
schema:publication	Clin Exp Allergy
resource representing a document's body	covid:5ea11faeeb6298b0c25bd67e921154aec2197964#body_text
is schema:about of	named entity 'IgE' named entity 'Objective' named entity 'IgE' named entity 'asthma' named entity 'antibodies' named entity 'major' named entity 'During' named entity 'IgE' named entity 'bacterial' named entity 'responses' named entity 'house dust mite' named entity 'ADMITTED TO' named entity 'RESULTS' named entity 'FOUND' named entity 'ASTHMA EXACERBATION' named entity 'VIRUS INFECTION' named entity 'RESPONSE TO' named entity 'HAVE' named entity 'BACTERIAL ANTIGEN' named entity 'CONCEPT' named entity 'INFECTED' named entity 'ANTIBODY' named entity 'sensitization' named entity 'IgE' named entity 'HDM' named entity 'frequent' named entity 'titres' named entity 'convalescence' named entity 'support' named entity 'responses' named entity 'marked' named entity 'type 2' named entity 'asthma' named entity 'asthma' named entity 'anti-bacterial' named entity 'IgG' named entity 'HDM' named entity 'IgE' named entity 'IgE' named entity 'HDM' named entity 'bacteria' named entity 'HDM' named entity 'virus' named entity 'IgE' named entity 'IgE' named entity 'allergic' named entity 'antibody' named entity 'allergic' named entity 'HDM' named entity 'allergens' named entity 'IgG antibody' named entity 'anti-bacterial' named entity 'HDM' named entity 'informed consent' named entity 'HDM' named entity 'highly conserved sequence' named entity 'Cardiff' named entity 'allergen' named entity 'HDM' named entity 'IgE' named entity 'IgE' named entity 'MRC' named entity 'antigen' named entity 'pathogens' named entity 'asthma exacerbations' named entity 'benzamidine'

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