About: The association between transforming growth factor beta1 polymorphism and susceptibility to pulmonary fibrosis: A meta-analysis (MOOSE compliant)

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About: The association between transforming growth factor beta1 polymorphism and susceptibility to pulmonary fibrosis: A meta-analysis (MOOSE compliant) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The association between transforming growth factor beta1 polymorphism and susceptibility to pulmonary fibrosis: A meta-analysis (MOOSE compliant)
Creator	Chen, Hui Liu, Xiao Gong, Jiening Jiang, Miao Su, Guangbao Xie, Miao Xin, Lili Xu, Muge Zhang, Geng
Source	PMC
abstract	Although many studies have investigated the association of single nucleotide polymorphisms (SNPs) in transforming growth factor beta1 (TGF-β1) gene with pulmonary fibrosis (PF), but their association is still controversial. To clarify this, we performed a meta-analysis. Studies related to TGF-β1 and PF were retrieved from PubMed, Medline, Embase, Scopus, and Wanfang (up to November 30, 2017). We targeted TGF-β1 SNPs that have been reported by ≥3 studies to be included in the current meta-analysis, resulting in only 1 final SNP (rs1800470). The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated in the models of allele comparison (T vs C), homozygote comparison (TT vs CC), dominant (TT vs TC + CC), recessive (TT + TC vs CC) to evaluate the strength of the associations. A total of 7 case-control studies were included in this meta-analysis. Overall, no significant association between TGF-β1 rs1800470 and PF was found (T vs C: OR [95% CI] = 0.96 [0.80, 1.15]; TT vs CC: 0.87 [0.61, 1.22]; TT vs TC + CC: 0.80 [0.62, 1.04]; TT + TC vs CC: 1.13 [0.83, 1.54]). In subgroup analyses by ethnicity or original disease, no statistically significant association between TGF-β1 rs1800470 polymorphisms and PF was demonstrated. This meta-analysis revealed that TGF-β1 rs1800470 polymorphism was not associated with susceptibility to PF development.
has issue date	2018-09-14(xsd:dateTime)
bibo:doi	10.1097/md.0000000000011876
bibo:pmid	30212926
has license	cc-by
sha1sum (hex)	5e93750f999d2d9a74e43f51d61de527957e8502
schema:url	https://doi.org/10.1097/md.0000000000011876
resource representing a document's title	The association between transforming growth factor beta1 polymorphism and susceptibility to pulmonary fibrosis: A meta-analysis (MOOSE compliant)
has PubMed Central identifier	PMC6155963
has PubMed identifier	30212926
schema:publication	Medicine (Baltimore)
resource representing a document's body	covid:5e93750f999d2d9a74e43f51d61de527957e8502#body_text
is schema:about of	named entity 'MOOSE' named entity 'SUSCEPTIBILITY' named entity 'METAANALYSIS' named entity 'CLARIFY' named entity 'TRANSFORMING GROWTH FACTOR BETA1' named entity 'GENE' named entity 'PERFORMED' named entity 'PULMONARY FIBROSIS' named entity 'COMPLIANT' named entity 'ASSOCIATION' named entity 'THEIR' named entity 'STUDIES' named entity 'BUT' named entity 'HAVE' named entity 'INVESTIGATED' named entity 'PULMONARY FIBROSIS' named entity 'SINGLE NUCLEOTIDE POLYMORPHISMS' named entity 'META-ANALYSIS' named entity 'TRANSFORMING GROWTH FACTOR BETA1' named entity 'ASSOCIATION' named entity 'POLYMORPHISM' covid:arg/5e93750f999d2d9a74e43f51d61de527957e8502 named entity 'pulmonary fibrosis' named entity 'meta-analysis' named entity 'SNPs' named entity 'gene' named entity 'transforming growth factor' named entity 'pulmonary fibrosis' named entity 'transforming growth factor' named entity 'Statistical significance' named entity 'lung fibrosis' named entity 'primary research' named entity 'inclusion and exclusion criteria' named entity 'pulmonary fibrosis' named entity 'IPF' named entity 'Publication bias' named entity 'control group' named entity '95% confidence interval' named entity 'meta-analysis' named entity 'biopsy' named entity 'SNPs' named entity 'meta-analysis' named entity 'summary statistics' named entity 'genotype' named entity 'pulmonary fibrosis' named entity 'odds ratio' named entity 'transforming growth factor' named entity 'Funnel plot' named entity 'genotype' named entity 'differentiation of cells' named entity 'gene polymorphism' named entity 'genetic polymorphisms' named entity 'polymorphism' named entity 'malignancy' named entity 'infection' named entity 'TGF-b1' named entity 'Forest plot' named entity 'pulmonary fibrosis' named entity 'meta-analysis' named entity 'fibrosis' named entity 'European Respiratory Society' named entity 'TGF-b1' named entity 'pulmonary fibrosis' named entity 'pulmonary fibrosis' named entity 'biological processes' named entity 'TGF-b1' named entity 'case-control studies' named entity 'genetic loci' named entity 'glycoproteins' named entity 'polymorphism' named entity 'diagnostic criteria' named entity 'heterogeneity' named entity 'metaanalysis'

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