About: SGLT2 inhibition and COVID‐19: The road not taken

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SGLT2 inhibition and COVID‐19: The road not taken
Creator	Das, Liza Dutta, Pinaki
Source	Medline; PMC
abstract	The COVID‐19 pandemic, caused by SARS‐CoV‐2, is an immense challenge for global healthcare. Diabetes mellitus, hypertension and obesity have been shown to portend poor prognosis in COVID‐19 despite no greater susceptibility to the infection (1). Chronic hypertension is commonly associated with vasculopathy which can predispose to severe infection. In patients with diabetes, severity is attributable to impaired innate, adaptive immunity, upregulation of ACE2 (entry receptor for SARS‐CoV2) by acute hyperglycemia and diabetic vasculopathy. The background of chronic low grade inflammation characterised by increased levels of IL‐6 and CRP in diabetes and obesity can also lead to an enhanced ‘cytokine storm’ in COVID‐19 (2). ACE2 expression on endothelial cells has been reported to cause viral mediated endothelitis and precipitate vascular dysfunction manifesting as acute respiratory distress syndrome as well as myocarditis, heart failure, arrhythmias, myocardial infarction and renal failure (3). In patients with pre‐existing comorbidities like hypertension, diabetes, obesity and chronic kidney disease, this new‐onset organ dysfunction can have deleterious additive effects.
has issue date	2020-07-10(xsd:dateTime)
bibo:doi	10.1111/eci.13339
bibo:pmid	32648935
has license	no-cc
sha1sum (hex)	5e8a0d72c259838944d800a064105d525f095640
schema:url	https://doi.org/10.1111/eci.13339
resource representing a document's title	SGLT2 inhibition and COVID‐19: The road not taken
has PubMed Central identifier	PMC7404515
has PubMed identifier	32648935
schema:publication	Eur J Clin Invest
resource representing a document's body	covid:5e8a0d72c259838944d800a064105d525f095640#body_text
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