About: Emergence and Evolution of Novel Reassortant Influenza A Viruses in Canines in Southern China

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Emergence and Evolution of Novel Reassortant Influenza A Viruses in Canines in Southern China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Emergence and Evolution of Novel Reassortant Influenza A Viruses in Canines in Southern China
Creator	Chen, Ying Wei, Zuzhang García-Sastre, Adolfo He, Ping Ouyang, Kang Nelson, Martha Huang, Weijian Wang, Guojun Zhou, Huabo Mo, Yanning Zhao, Weifeng Trovão, Nídia
source	Medline; PMC
abstract	The capacity of influenza A viruses (IAVs) to host jump from animal reservoir species to humans presents an ongoing pandemic threat. Birds and swine are considered major reservoirs of viral genetic diversity, whereas equines and canines have historically been restricted to one or two stable IAV lineages with no transmission to humans. Here, by sequencing the complete genomes of 16 IAVs obtained from canines in southern China (Guangxi Zhuang Autonomous Region [Guangxi]) in 2013 to 2015, we demonstrate that the evolution of canine influenza viruses (CIVs) in Asian dogs is increasingly complex, presenting a potential threat to humans. First, two reassortant H1N1 virus genotypes were introduced independently from swine into canines in Guangxi, including one genotype associated with a zoonotic infection. The genomes contain segments from three lineages that circulate in swine in China: North American triple reassortant H3N2, Eurasian avian-like H1N1, and pandemic H1N1. Furthermore, the swine-origin H1N1 viruses have transmitted onward in canines and reassorted with the CIV-H3N2 viruses that circulate endemically in Asian dogs, producing three novel reassortant CIV genotypes (H1N1r, H1N2r, and H3N2r [r stands for reassortant]). CIVs from this study were collected primarily from pet dogs presenting with respiratory symptoms at veterinary clinics, but dogs in Guangxi are also raised for meat, and street dogs roam freely, creating a more complex ecosystem for CIV transmission. Further surveillance is greatly needed to understand the full genetic diversity of CIV in southern China, the nature of viral emergence and persistence in the region’s diverse canine populations, and the zoonotic risk as the viruses continue to evolve.
has issue date	2018-06-05(xsd:dateTime)
bibo:doi	10.1128/mbio.00909-18
bibo:pmid	29871917
has license	cc-by
sha1sum (hex)	5e545b25250d9239c3096fa6925fad84c88199cf
schema:url	https://doi.org/10.1128/mbio.00909-18
resource representing a document's title	Emergence and Evolution of Novel Reassortant Influenza A Viruses in Canines in Southern China
has PubMed Central identifier	PMC5989073
has PubMed identifier	29871917
schema:publication	mBio
resource representing a document's body	covid:5e545b25250d9239c3096fa6925fad84c88199cf#body_text
is schema:about of	named entity 'SOUTHERN' named entity 'CANINES' named entity 'EMERGENCE' named entity 'INFLUENZA A' named entity 'NOVEL' named entity 'EVOLUTION' named entity 'CHINA' named entity 'VIRUSES' named entity 'Evolution' named entity 'Emergence' named entity 'Canines' named entity 'Influenza' named entity 'Viruses' named entity 'virus genome' named entity 'interspecies transmission' named entity 'viruses' named entity 'H1N1' named entity 'canines' named entity 'viruses' named entity 'excl' named entity 'genotypes' named entity 'clade' named entity 'viruses' named entity 'genotypes' named entity 'China' named entity 'IAV' named entity 'host species' named entity 'Guangxi' named entity 'genetic diversity' named entity 'viruses' named entity 'IAV' named entity 'canines' named entity 'China' named entity 'H3N8' named entity 'mammals' named entity 'mammals' named entity 'canines' named entity 'United States' named entity 'China' named entity 'viruses' named entity 'fusion protein' named entity 'Asia' named entity 'Guangdong' named entity 'China' named entity 'canines' named entity 'posterior distribution' named entity 'MCC' named entity 'viruses' named entity 'Guangxi' named entity 'canines' named entity 'dog' named entity 'Sequence alignments' named entity 'canines' named entity 'PCR' named entity 'influenza virus' named entity 'viruses' named entity 'viruses' named entity 'PCR' named entity 'veterinary clinics' named entity 'innate immune responses' named entity 'serum' named entity 'IAV' named entity 'secondary market' named entity 'H1N1' named entity 'Guangxi' named entity 'virus isolation' named entity 'evolution' named entity 'viruses' named entity 'canines' named entity 'viruses'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software