About: Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014
Creator	Alraddadi, Basem Feikin, Daniel Watson, John Curns, Aaron Qutub, Mohammed Shabouni, Omaima Wolff, Bernard Watson, J Arabia, Saudi Feikin, D Madani, Tariq Curns, A Oboho, Ikwo Tomczyk, Sara Al-Raddadi, B Center, Jeddah Madani, T Oboho, I Qutub, M Shabouni, O Tomczyk, S Wolff, B
source	Medline; PMC
abstract	Middle East respiratory syndrome coronavirus (MERS-CoV) causes a spectrum of illness. We evaluated whether cycle threshold (C(t)) values (which are inversely related to virus load) were associated with clinical severity in patients from Saudi Arabia whose nasopharyngeal specimens tested positive for this virus by real-time reverse transcription PCR. Among 102 patients, median C(t) of 31.0 for the upstream of the E gene target for 41 (40%) patients who died was significantly lower than the median of 33.0 for 61 survivors (p = 0.0087). In multivariable regression analyses, risk factors for death were age >60 years), underlying illness, and decreasing C(t) for each 1-point decrease in C(t)). Results were similar for a composite severe outcome (death and/or intensive care unit admission). More data are needed to determine whether modulation of virus load by therapeutic agents affects clinical outcomes.
has issue date	2015-11-01(xsd:dateTime)
bibo:doi	10.3201/eid2111.150764
bibo:pmid	26488195
has license	no-cc
sha1sum (hex)	5e25c11546305667e32023f9bdae2c5a3bc7c25c
schema:url	https://doi.org/10.3201/eid2111.150764
resource representing a document's title	Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014
has PubMed Central identifier	PMC4622256
has PubMed identifier	26488195
schema:publication	Emerg Infect Dis
resource representing a document's body	covid:5e25c11546305667e32023f9bdae2c5a3bc7c25c#body_text
is schema:about of	named entity 'viral infections' named entity 'Jeddah' named entity 'KSA' named entity 'Switzerland' named entity 'confounders' named entity 'genetics' named entity 'risk factors' named entity 'immunotherapy' named entity 'risk factors' named entity 'Wilcoxon rank sum test' named entity 'virus' named entity 'MERS-CoV' named entity 'higher risk' named entity 'MERS-CoV' named entity 'renal diseases' named entity 'virus' named entity 'MERS-CoV' named entity 'lung' named entity 'upper respiratory tract' named entity 'MERS-CoV' named entity 'Roche' named entity 'inoculum' named entity 'virus' named entity 'asymptomatic infection' named entity 'MERS-CoV' named entity 'MERS-CoV' named entity 'Spearman rank correlation coefficient' named entity 'nasopharyngeal swab' named entity 'lower respiratory tract' named entity 'nasopharyngeal swab' named entity 'categorical variable' named entity 'nasopharyngeal swab' named entity 'parameter estimate' named entity 'mRNA' named entity 'range 15' named entity 'virus' named entity 'virus' named entity 'virus' named entity 'reverse transcription PCR' named entity 'gene' named entity 'nasopharyngeal swab' named entity 'KSA' named entity 'statistical significance' named entity 'MERS' named entity 'risk factors' named entity 'ascertainment bias' named entity 'dyspnea' named entity '1.08' named entity 'MERS-CoV' named entity 'national identification number' named entity 'bronchoalveolar lavage' named entity 'virus' named entity 'inflammatory response' named entity 'Jeddah' named entity 'Berlin' named entity 'Saudi Arabia' named entity 'MERS-CoV' named entity 'gene' named entity 'lower respiratory tract' named entity 'virus'

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