About: Survival functions for defining a clinical management Lost To Follow-Up (LTFU) cut-off in Antiretroviral Therapy (ART) program in Zomba, Malawi

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About: Survival functions for defining a clinical management Lost To Follow-Up (LTFU) cut-off in Antiretroviral Therapy (ART) program in Zomba, Malawi Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Survival functions for defining a clinical management Lost To Follow-Up (LTFU) cut-off in Antiretroviral Therapy (ART) program in Zomba, Malawi
Creator	Escobar, Michael Rachlis, Beth Cole, Donald Van Lettow, Monique
source	Medline; PMC
abstract	BACKGROUND: While, lost to follow-up (LTFU) from antiretroviral therapy (ART) can be considered a catch-all category for patients who miss scheduled visits or medication pick-ups, operational definitions and methods for defining LTFU vary making comparisons across programs challenging. Using weekly cut-offs, we sought to determine the probability that an individual would return to clinic given that they had not yet returned in order to identify the LTFU cut-off that could be used to inform clinical management and tracing procedures. METHODS: Individuals who initiated ART with Dignitas International supported sites (n = 22) in Zomba, Malawi between January 1 2007-June 30 2010 and were ≥ 1 week late for a follow-up visit were included. Lateness was categorized using weekly cut-offs from ≥1 to ≥26 weeks late. At each weekly cut-off, the proportion of patients who returned for a subsequent follow-up visit were identified. Cumulative Distribution Functions (CDFs) were plotted to determine the probability of returning as a function of lateness. Hazard functions were plotted to demonstrate the proportion of patients who returned each weekly interval relative to those who had yet to return. RESULTS: In total, n = 4484 patients with n = 7316 follow-up visits were included. The number of included follow-up visits per patient ranged from 1–10 (median: 1). Both the CDF and hazard function demonstrated that after being ≥9 weeks late, the proportion of new patients who returned relative to those who had yet to return decreased substantially. CONCLUSIONS: We identified a LTFU definition useful for clinical management. The simple functions plotted here did not require advanced statistical expertise and were created using Microsoft Excel, making it a particularly practical method for HIV programs in resource-constrained settings. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12911-016-0290-7) contains supplementary material, which is available to authorized users.
has issue date	2016-05-05(xsd:dateTime)
bibo:doi	10.1186/s12911-016-0290-7
bibo:pmid	27150958
has license	cc-by
sha1sum (hex)	5d9e52011787ca962e5391dd027c6641a37f9cba
schema:url	https://doi.org/10.1186/s12911-016-0290-7
resource representing a document's title	Survival functions for defining a clinical management Lost To Follow-Up (LTFU) cut-off in Antiretroviral Therapy (ART) program in Zomba, Malawi
has PubMed Central identifier	PMC4857410
has PubMed identifier	27150958
schema:publication	BMC Med Inform Decis Mak
resource representing a document's body	covid:5d9e52011787ca962e5391dd027c6641a37f9cba#body_text
is schema:about of	named entity 'subsequent' named entity 'Distribution' named entity 'total' named entity 'returning' named entity 'making' named entity 'created' named entity 'Antiretroviral Therapy (ART)' named entity 'defining' named entity 'MALAWI' named entity 'FOLLOW-UP' named entity 'CLINIC' named entity 'TO IDENTIFY' named entity 'LOST TO FOLLOW-UP' named entity 'MALAWI' named entity 'CATCH' named entity 'RESULTS' named entity 'A51' named entity 'LATE' named entity 'LOST TO FOLLOW-UP' named entity 'CONSTRAINED' named entity 'PATIENT' named entity 'FUNCTION' named entity 'SETTINGS' named entity 'SCHEDULED' named entity 'METHOD' named entity 'DID' named entity 'LTFU' named entity 'INTERVAL' named entity 'INTERNATIONAL' named entity 'NEW' named entity 'LATENESS' named entity 'PROBABILITY' named entity 'VISITS' named entity 'FUNCTIONS' named entity 'DEFINING' named entity 'PROGRAMS' named entity 'DECREASED' named entity 'USED' named entity 'BACKGROUND' named entity 'ANTIRETROVIRAL THERAPY' named entity 'SUBSEQUENT' named entity 'HIV' named entity 'ANTIRETROVIRAL THERAPY' named entity 'PROGRAM' named entity 'CUT' named entity 'TO INFORM' named entity 'INCLUDED' named entity 'ART' named entity 'GIVEN' named entity 'JUNE' named entity 'ACROSS' named entity 'UPS' named entity 'RETURN' named entity 'MICROSOFT EXCEL' named entity 'CUMULATIVE' named entity '4484' named entity 'ADVANCED' named entity '1-10' named entity 'RETURNED' named entity 'INDIVIDUAL' named entity 'WEEKLY' named entity 'PROBABILITY OF' named entity 'COULD BE' named entity 'WEEKS' named entity 'BEING' named entity 'CATEGORIZED' named entity 'EXPERTISE' named entity 'DISTRIBUTION' named entity 'PROPORTION' named entity 'USING' named entity 'SITES' named entity 'NUMBER OF' named entity 'PLOTTED' named entity 'CLINICAL MANAGEMENT' named entity 'RESOURCE' named entity 'DEFINING' named entity 'CONCLUSIONS' named entity 'CREATED'

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