About: Identification of influenza A nucleoprotein as an antiviral target

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About: Identification of influenza A nucleoprotein as an antiviral target Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of influenza A nucleoprotein as an antiviral target
Creator	Zheng, Bo-Jian Yuen, Kwok-Yung Guan, Yi Huang, Jian-Dong Yang, Dan Chan, Che-Man Chen, Guanhua Hu, Lihong Sun, Jian Chen, Honglin Wang, Pui Chan, Mei-Po Dai, Jun Kao, Richard Lau, Lai-Shan Madar, Jason Tsui, Wayne
Source	Medline; PMC
abstract	Influenza A remains a significant public health challenge because of the emergence of antigenically shifted or highly virulent strains(1,2,3,4,5). Antiviral resistance to available drugs such as adamantanes or neuraminidase inhibitors has appeared rapidly(6,7,8,9), creating a need for new antiviral targets and new drugs for influenza virus infections. Using forward chemical genetics, we have identified influenza A nucleoprotein (NP) as a druggable target and found a small-molecule compound, nucleozin, that triggers the aggregation of NP and inhibits its nuclear accumulation. Nucleozin impeded influenza A virus replication in vitro with a nanomolar median effective concentration (EC(50)) and protected mice challenged with lethal doses of avian influenza A H5N1. Our results demonstrate that viral NP is a valid target for the development of small-molecule therapies. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nbt.1638) contains supplementary material, which is available to authorized users.
has issue date	2010-05-30(xsd:dateTime)
bibo:doi	10.1038/nbt.1638
bibo:pmid	20512121
has license	no-cc
sha1sum (hex)	5d994360c7fc1c679fc2b8c17c84689ba0599806
schema:url	https://doi.org/10.1038/nbt.1638
resource representing a document's title	Identification of influenza A nucleoprotein as an antiviral target
has PubMed Central identifier	PMC7097325
has PubMed identifier	20512121
schema:publication	Nat Biotechnol
resource representing a document's body	covid:5d994360c7fc1c679fc2b8c17c84689ba0599806#body_text
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