About: Hypothalamic digoxin – central role in conscious perception, neuroimmunoendocrine integration and coordination of cellular function

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About: Hypothalamic digoxin – central role in conscious perception, neuroimmunoendocrine integration and coordination of cellular function – relation to hemispheric dominance Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hypothalamic digoxin – central role in conscious perception, neuroimmunoendocrine integration and coordination of cellular function – relation to hemispheric dominance
Creator	Kurup, Parameswara Kurup, Ravi
Source	Elsevier; Medline; PMC
abstract	Abstract A family with a high prevalence of Parkinson’s disease, schizophrenia, neoplasms, syndrome-X, rheumatoid arthritis and epilepsy has been described. The psychological behavioural patterns of the family were as follows – creativity and high IQ, hypersexual behaviour, reduced appetite and eating behaviour, insomnia and reduced sleep patterns, increased tendency for spirituality, increased tendency for addiction, less of bonding and affectionate behaviour and left handedness. Digoxin, an endogenous Na+–K+ ATPase inhibitor secreted by the hypothalamus, was found to be elevated and RBC membrane Na+–K+ ATPase activity was found to be reduced in all the disorders and in the indexed family studied. Hypothalamic digoxin can modulate conscious perception and its dysfunction may lead to schizophrenia. Digoxin can also preferentially upregulate tryptophan transport over tyrosine resulting in increased levels of depolarising tryptophan catabolites – serotonin, quinolinic acid, strychnine and nicotine and decreased levels of hyperpolarising tyrosine catabolites dopamine, noradrenaline and morphine contributing to membrane Na+–K+ ATPase inhibition in all the above disorders and the indexed family. Digoxin induced membrane Na+–K+ ATPase inhibition can result in increased intracellular Ca2+ and reduced Mg++ levels leading to glutamate excitotoxicity, oncogene activation and immune activation. Digoxin induced altered Ca++/Mg++ ratios, reduced ubiquinone and increased dolichol can affect glycoconjugate metabolism, membrane formation and structure and mitochondrial function leading to the diverse disorders described above including those in the indexed family. The isoprenoid pathway and neurotransmitter patterns were compared in right-handed/left hemispheric dominant and left-handed/right hemispheric dominant individuals. The biochemical patterns in the indexed family and the diverse disorders studied correlated with those obtained in right hemispheric dominance. The hyperdigoxinemic state indicates right hemispheric dominance. Hypothalamic digoxin can thus function as the master conductor of the neuroimmunoendocrine orchestra and co-ordinate the functions of various cellular organelles.
has issue date	2003-02-28(xsd:dateTime)
bibo:doi	10.1016/s0306-9877(02)00382-1
bibo:pmid	12606243
has license	els-covid
sha1sum (hex)	5d714e78135125c4abb4d0e1624766b65af0746f
schema:url	https://doi.org/10.1016/s0306-9877%2802%2900382-1
resource representing a document's title	Hypothalamic digoxin – central role in conscious perception, neuroimmunoendocrine integration and coordination of cellular function – relation to hemispheric dominance
has PubMed Central identifier	PMC7125598
has PubMed identifier	12606243
schema:publication	Medical Hypotheses
resource representing a document's body	covid:5d714e78135125c4abb4d0e1624766b65af0746f#body_text
is schema:about of	named entity 'structure' named entity 'catabolites' named entity 'affectionate' named entity 'glutamate' named entity 'ubiquinone' named entity 'reduced' named entity 'membrane' named entity 'leading' named entity 'reduced' named entity 'RATIOS' named entity 'CATABOLITES' named entity 'RESULT' named entity 'ELEVATED' named entity 'TRYPTOPHAN' named entity 'FOLLOWS' named entity 'CONSCIOUS' named entity 'INTRACELLULAR' named entity 'BONDING' named entity 'REDUCED UBIQUINONE' named entity 'FUNCTIONS' named entity 'CREATIVITY' named entity 'PATTERNS' named entity 'SEROTONIN' named entity 'ALTERED' named entity 'LEADING' named entity 'EPILEPSY' named entity 'ORGANELLES' named entity 'NORADRENALINE' named entity 'ONCOGENE ACTIVATION' named entity 'DOMINANCE' named entity 'VARIOUS' named entity 'FUNCTION' covid:arg/5d714e78135125c4abb4d0e1624766b65af0746f named entity 'DEPOLARISING' named entity 'DIGOXIN' named entity 'HEMISPHERIC' named entity 'STATE' named entity 'FORMATION' named entity 'IMMUNE ACTIVATION' named entity 'INCLUDING' named entity 'GLUTAMATE EXCITOTOXICITY' named entity 'DIGOXIN' named entity 'CELLULAR FUNCTION' named entity 'ROLE' named entity 'PERCEPTION' named entity 'HYPOTHALAMIC' named entity 'DOMINANCE' named entity 'CENTRAL' named entity 'CONSCIOUS' named entity 'INDIVIDUALS' named entity 'STRUCTURE' named entity 'COMPARED' named entity 'SCHIZOPHRENIA' named entity 'PARKINSON' named entity 'INDEXED' named entity 'INCREASED TENDENCY' named entity 'BEHAVIOURAL' named entity 'MITOCHONDRIAL FUNCTION' named entity 'DOLICHOL' named entity 'DOPAMINE' named entity 'INTEGRATION' named entity 'ORCHESTRA' named entity 'LEVELS' named entity 'GLYCOCONJUGATE' named entity 'TRYPTOPHAN TRANSPORT' named entity 'OBTAINED' named entity 'NEUROTRANSMITTER' named entity 'HIGH' named entity 'NEOPLASMS' named entity 'PERCEPTION' named entity 'DISORDERS' named entity 'DOMINANT' named entity 'ORDINATE' named entity 'HIGH PREVALENCE' named entity 'ENDOGENOUS' named entity 'INCREASED' named entity 'COORDINATION' named entity 'RELATION' named entity 'DESCRIBED' named entity 'BIOCHEMICAL'

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