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About:
Prevalence and Correlation of Infectious Agents in Hospitalized Children with Acute Respiratory Tract Infections in Central China
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schema:ScholarlyArticle
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covidontheweb.inria.fr
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Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
Prevalence and Correlation of Infectious Agents in Hospitalized Children with Acute Respiratory Tract Infections in Central China
Creator
Liu, Jia
Wu, Jianguo
Liu, Weiyong
Liu, Yingle
Li, Fu
Li, Tongya
Xiong, Ying
Liu, Wen
Li, Y
Qin, Kai
Wen, Zhou
Jude, St
Russell, Charles
Xiong, Ai
Source
PMC
abstract
Acute respiratory tract infections (ARTIs) are associated with significant morbidity and mortality worldwide, especially in children under the age of 5 years. Almost 2 million children die from ARTIs each year, and most of them are from developing countries. The prevalence and correlation of pathogens in ARTIs are poorly understood, but are critical for improving case prevention, treatment, and management. In this study, we investigated the prevalence and correlation of infectious agents in children with ARTIs. A total of 39,756 children with one or more symptoms, including fever, cough, sore throat, tonsillitis, pharyngitis, herpangina, pneumonia, and bronchiolitis, were enrolled in the study. All patients were hospitalized in Wuhan Children’s Hospital between October 1, 2010 and September 30, 2012, and were evaluated for infectious agents. Pathogens, including Mycoplasma pneumoniae, influenza A virus, influenza B virus, adenoviruses, respiratory syncytial virus, parainfluenza virus, Legionella pneumophila, Chlamydophila pneumoniae, and Coxiella burnetii, were screened simultaneously in patient blood samples using anti-pathogen IgM tests. Regression analysis was used to reveal correlations among the pathogens. Our results showed that one or more pathogens were identified in 10,206 patients, and that Mycoplasma pneumoniae, adenoviruses, and influenza B virus were the leading infectious agents. Mixed-infections of pathogens were detected in 2,391 cases, with Mycoplasma pneumoniae as the most frequent pathogen. The most common agents in the co-infections were Mycoplasma pneumoniae and influenza B virus. Regression analysis revealed a linear correlation between the proportion of mixed infections and the incidence of multi-pathogen infections. The prevalence of infectious agents in children with ARTIs was determined. Equations were established to estimate multiple infections by single-pathogen detection. This revealed a linear correlation for pathogens in children with ARTIs. This study provides useful information for improving case prevention and management.
has issue date
2015-03-09
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)
bibo:doi
10.1371/journal.pone.0119170
bibo:pmid
25751402
has license
cc-by
sha1sum (hex)
5d6c145129db8973b797726818f229dfaa997f11
schema:url
https://doi.org/10.1371/journal.pone.0119170
resource representing a document's title
Prevalence and Correlation of Infectious Agents in Hospitalized Children with Acute Respiratory Tract Infections in Central China
has PubMed Central identifier
PMC4353725
has PubMed identifier
25751402
schema:publication
PLoS One
resource representing a document's body
covid:5d6c145129db8973b797726818f229dfaa997f11#body_text
is
schema:about
of
named entity 'CHINA'
named entity 'ACUTE'
named entity 'MULTI'
named entity 'EQUATIONS'
named entity 'PARAINFLUENZA VIRUS'
named entity 'WUHAN'
named entity '30%'
named entity 'COXIELLA BURNETII'
named entity 'MILLION'
named entity 'ESTIMATE'
named entity 'CASES'
named entity 'ADENOVIRUSES'
named entity 'CO-INFECTIONS'
named entity 'LINEAR'
named entity 'POORLY'
named entity 'INFLUENZA B VIRUS'
named entity 'ACUTE'
named entity 'MIXED'
named entity 'PATHOGEN DETECTION'
named entity 'PROVIDES'
named entity 'DIE'
named entity 'LEGIONELLA PNEUMOPHILA'
named entity 'INVESTIGATED'
named entity 'OCTOBER'
named entity 'HERPANGINA'
named entity 'IMPROVING'
named entity 'TOTAL'
named entity 'FEVER'
named entity 'MORBIDITY AND MORTALITY'
named entity 'CORRELATION'
named entity 'INFLUENZA A VIRUS'
named entity 'PNEUMONIA'
named entity 'COUGH'
named entity 'DETERMINED'
named entity 'PROPORTION'
named entity 'RESULTS'
named entity 'SYMPTOMS'
named entity 'RESPIRATORY TRACT INFECTIONS'
named entity 'USEFUL INFORMATION'
named entity 'CASE'
named entity 'RESPIRATORY SYNCYTIAL VIRUS'
named entity 'SORE THROAT'
named entity 'STUDY'
named entity 'AGE'
named entity 'UNDERSTOOD'
named entity 'HOSPITALIZED'
named entity 'SIGNIFICANT'
named entity 'CHILDREN'
named entity 'ESTABLISHED'
named entity 'TREATMENT'
named entity 'INFECTIOUS AGENTS'
named entity 'DEVELOPING COUNTRIES'
named entity 'EVALUATED'
named entity 'ENROLLED'
named entity '10%'
named entity 'MANAGEMENT'
named entity 'HOSPITALIZED CHILDREN'
named entity 'PHARYNGITIS'
named entity 'MULTIPLE INFECTIONS'
named entity 'HOSPITAL'
named entity 'SIMULTANEOUSLY'
named entity 'REVEALED'
named entity 'COMMON'
named entity 'BLOOD SAMPLES'
named entity 'MOST OF'
named entity 'INFECTIONS'
named entity 'BUT'
named entity '27S'
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