About: Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors
Creator	Kilianski, Andy Baker, Susan
Source	Elsevier; Medline; PMC
abstract	To combat the public health threat from emerging coronaviruses (CoV), the development of antiviral therapies with either virus-specific or pan-CoV activities is necessary. An important step in antiviral drug development is the screening of potential inhibitors in cell-based systems. The recent emergence of the Middle East respiratory syndrome (MERS)-CoV necessitates adapting methods that have been used to identify antivirals against the severe, acute respiratory syndrome (SARS)-CoV and developing new approaches to more efficiently screen antiviral drugs. In this article we review cell-based assays using infectious virus (BSL-3) and surrogate assays (BSL-2) that can be implemented to accelerate antiviral development against MERS-CoV and future emergent coronaviruses. This paper forms part of a series of invited articles in Antiviral Research on “From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses.”
has issue date	2014-01-01(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2013.11.004
bibo:pmid	24269477
has license	bronze-oa
sha1sum (hex)	5d0f353b8581c16ead66fbc58ec16c0a6ff8777d
schema:url	https://doi.org/10.1016/j.antiviral.2013.11.004
resource representing a document's title	Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors
has PubMed Central identifier	PMC3931262
has PubMed identifier	24269477
schema:publication	Antiviral Research
resource representing a document's body	covid:5d0f353b8581c16ead66fbc58ec16c0a6ff8777d#body_text
is schema:about of	named entity 'ANTIVIRAL' named entity 'CELL' named entity 'Middle East respiratory syndrome' named entity 'pathogenic' named entity 'emergence' named entity 'virus-specific' named entity 'antivirals' named entity 'inhibitors' named entity 'SPECIFIC' named entity 'TO IDENTIFY' named entity 'SARS' named entity 'HUMAN' named entity 'REVIEW' named entity 'FUTURE' named entity 'RESEARCH' named entity 'INHIBITORS' named entity 'IMPORTANT' named entity 'DEVELOPMENT' named entity 'ADAPTING' named entity 'STEP' named entity 'ANTIVIRAL DRUGS' named entity 'DEVELOPING' named entity 'NECESSARY' named entity 'THERAPIES' named entity 'DEVELOPING' named entity 'BROAD' named entity 'VIRUS' named entity 'INFECTIOUS' named entity 'EITHER' named entity 'EMERGENT' named entity 'VIRUS' named entity 'YEARS' named entity 'SPECTRUM' named entity 'SCREENING' named entity 'INHIBITORS' named entity 'BASED' named entity 'CORONAVIRUSES' named entity 'ACTIVITIES' named entity 'METHODS' named entity 'CELL' named entity 'USED' named entity 'SPECIFIC' named entity 'THREAT' named entity 'RECENT' named entity 'ANTIVIRALS' named entity 'FORMS' named entity 'ACCELERATE' named entity 'HAVE' named entity 'BASED' named entity 'PATHOGENIC' named entity 'APPROACHES' named entity 'PART OF' named entity 'ARTICLE' named entity 'MERS' named entity 'POTENTIAL' named entity 'NEW' named entity 'USING' named entity 'SCREEN' named entity 'ANTIVIRAL DRUG' named entity 'SCREENING' named entity 'DRUG DEVELOPMENT' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'PAPER' named entity 'EMERGENCE' named entity 'COMBAT' named entity 'ANTIVIRAL' named entity 'SURROGATE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'IMPLEMENTED' named entity 'CORONAVIRUSES' named entity 'SYSTEMS' named entity 'SERIES' named entity 'PUBLIC HEALTH' named entity 'HIGHLY' named entity 'PAN' named entity 'antiviral' named entity '10 years' named entity 'identify' named entity 'future' named entity 'SARS-CoV'

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