About: A review on the eco-epidemiology and clinical management of human granulocytic anaplasmosis and its agent in Europe

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About: A review on the eco-epidemiology and clinical management of human granulocytic anaplasmosis and its agent in Europe Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A review on the eco-epidemiology and clinical management of human granulocytic anaplasmosis and its agent in Europe
Creator	Zeller, Herve Mihalca, Andrei Cutler, Sally Vayssier-Taussat, Muriel Estrada-Peña, Agustín Matei, Ioana Potkonjak, Aleksandar Varela-Castro, Lucía
Source	PMC
abstract	Anaplasma phagocytophilum is the agent of tick-borne fever, equine, canine and human granulocytic anaplasmosis. The common route of A. phagocytophilum transmission is through a tick bite, the main vector in Europe being Ixodes ricinus. Despite the apparently ubiquitous presence of the pathogen A. phagocytophilum in ticks and various wild and domestic animals from Europe, up to date published clinical cases of human granulocytic anaplasmosis (HGA) remain rare compared to the worldwide status. It is unclear if this reflects the epidemiological dynamics of the human infection in Europe or if the disease is underdiagnosed or underreported. Epidemiologic studies in Europe have suggested an increased occupational risk of infection for forestry workers, hunters, veterinarians, and farmers with a tick-bite history and living in endemic areas. Although the overall genetic diversity of A. phagocytophilum in Europe is higher than in the USA, the strains responsible for the human infections are related on both continents. However, the study of the genetic variability and assessment of the difference of pathogenicity and infectivity between strains to various hosts has been insufficiently explored to date. Most of the European HGA cases presented as a mild infection, common clinical signs being pyrexia, headache, myalgia and arthralgia. The diagnosis of HGA in the USA was recommended to be based on clinical signs and the patient’s history and later confirmed using specialized laboratory tests. However, in Europe since the majority of cases are presenting as mild infection, laboratory tests may be performed before the treatment in order to avoid antibiotic overuse. The drug of choice for HGA is doxycycline and because of potential for serious complication the treatment should be instituted on clinical suspicion alone.
has issue date	2019-12-21(xsd:dateTime)
bibo:doi	10.1186/s13071-019-3852-6
bibo:pmid	31864403
has license	cc-by
sha1sum (hex)	5ce1a59d7c804025b82f5c839d5f55d8b4351412
schema:url	https://doi.org/10.1186/s13071-019-3852-6
resource representing a document's title	A review on the eco-epidemiology and clinical management of human granulocytic anaplasmosis and its agent in Europe
has PubMed Central identifier	PMC6925858
has PubMed identifier	31864403
schema:publication	Parasit Vectors
resource representing a document's body	covid:5ce1a59d7c804025b82f5c839d5f55d8b4351412#body_text
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