About: In-Depth Bioinformatic Analyses of Nidovirales Including Human SARS-CoV-2, SARS-CoV, MERS-CoV Viruses Suggest Important Roles of Non-canonical Nucleic Acid Structures in Their Lifecycles

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: In-Depth Bioinformatic Analyses of Nidovirales Including Human SARS-CoV-2, SARS-CoV, MERS-CoV Viruses Suggest Important Roles of Non-canonical Nucleic Acid Structures in Their Lifecycles Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In-Depth Bioinformatic Analyses of Nidovirales Including Human SARS-CoV-2, SARS-CoV, MERS-CoV Viruses Suggest Important Roles of Non-canonical Nucleic Acid Structures in Their Lifecycles
Creator	Ruggiero, Emanuela Frasson, Ilaria Bartas, Martin Bohálová, Natália Brázda, Václav Cantara, Alessio Jagelská, Eva Malachová, Kateřina Pečinka, Petr Porubiaková, Otília Stachurová, Tereza Volná, Adriana
Source	Medline; PMC
abstract	Non-canonical nucleic acid structures play important roles in the regulation of molecular processes. Considering the importance of the ongoing coronavirus crisis, we decided to evaluate genomes of all coronaviruses sequenced to date (stated more broadly, the order Nidovirales) to determine if they contain non-canonical nucleic acid structures. We discovered much evidence of putative G-quadruplex sites and even much more of inverted repeats (IRs) loci, which in fact are ubiquitous along the whole genomic sequence and indicate a possible mechanism for genomic RNA packaging. The most notable enrichment of IRs was found inside 5′UTR for IRs of size 12+ nucleotides, and the most notable enrichment of putative quadruplex sites (PQSs) was located before 3′UTR, inside 5′UTR, and before mRNA. This indicates crucial regulatory roles for both IRs and PQSs. Moreover, we found multiple G-quadruplex binding motifs in human proteins having potential for binding of SARS-CoV-2 RNA. Non-canonical nucleic acids structures in Nidovirales and in novel SARS-CoV-2 are therefore promising druggable structures that can be targeted and utilized in the future.
has issue date	2020-07-03(xsd:dateTime)
bibo:doi	10.3389/fmicb.2020.01583
bibo:pmid	32719673
has license	cc-by
sha1sum (hex)	5cb60344bce54e3d8e5ab59b2e408a509fa8489c
schema:url	https://doi.org/10.3389/fmicb.2020.01583
resource representing a document's title	In-Depth Bioinformatic Analyses of Nidovirales Including Human SARS-CoV-2, SARS-CoV, MERS-CoV Viruses Suggest Important Roles of Non-canonical Nucleic Acid Structures in Their Lifecycles
has PubMed Central identifier	PMC7347907
has PubMed identifier	32719673
schema:publication	Front Microbiol
resource representing a document's body	covid:5cb60344bce54e3d8e5ab59b2e408a509fa8489c#body_text
is schema:about of	named entity 'decided' named entity 'inverted repeats' named entity 'IRs' covid:arg/5cb60344bce54e3d8e5ab59b2e408a509fa8489c named entity 'structures' named entity 'acid' named entity 'G-quadruplex' named entity 'structures' named entity 'This' named entity 'IRs' named entity 'RNA' named entity 'genomes' named entity 'SARS-CoV-2' named entity 'Roles' named entity 'UTR' named entity 'RNA' named entity 'sequenced' named entity 'RNA' named entity 'Nucleic Acid' named entity 'SARS-CoV-2' named entity 'human coronaviruses' named entity 'Nglycosylation' named entity 'drug target' named entity 'SARS-CoV-2' named entity 'phylogenetically conserved' named entity 'genome' named entity 'subgenomic mRNA' named entity 'SARS' named entity 'genomes' named entity 'G-quadruplex' named entity 'TRA2A' named entity 'SARS-CoV-2' named entity 'Microsoft Excel' named entity 'G-quadruplex' named entity 'Severe acute respiratory syndrome coronavirus 2' named entity 'glycoproteins' named entity 'flavonoid' named entity 'viral RNA' named entity 'ssRNA' named entity 'SARS-CoV' named entity 'viruses' named entity 'IRs' named entity 'NCBI' named entity 'Microbiology' named entity 'SARS-CoV' named entity 'FASTA format' named entity 'RNA-binding proteins' named entity 'adenine' named entity 'Ankyrin' named entity '0.80' named entity 'negative control' named entity 'TRA2A' named entity 'DNA viruses' named entity 'Planarian' named entity 'viruses' named entity 'MERS-CoV' named entity 'transcription machinery' named entity 'genome' named entity 'RNA' named entity 'RNA' named entity 'virus' named entity 'guanine' named entity 'RNA-binding' named entity 'positive strand' named entity 'binding motif' named entity 'host cells' named entity 'IRs' named entity 'SARS-CoV-2' named entity 'RNA' named entity 'SARS-CoV'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software