About: Human coronaviruses: Clinical features and phylogenetic analysis

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About: Human coronaviruses: Clinical features and phylogenetic analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human coronaviruses: Clinical features and phylogenetic analysis
Creator	Lin, Cheng-Wen Li, Shih-Wen
Source	Elsevier; Medline; PMC
abstract	Strains of human coronavirus (HCoV), namely HCoV-OC43, HCoV-229E, HCoV-NL63, and HCoV-HKU1, primarily infect the upper respiratory and gastrointestinal tracts and are the most common cause of non-rhinovirus-induced common cold in humans. Although the manifestations of coronavirus infection (i.e., rhinorrhea, sneezing, cough, nasal obstruction, and bronchitis) are generally self-limiting in healthy adults, certain strains such as HCoV-NL63 and HCoV-HKU1 can cause severe lower respiratory tract infection and febrile seizure, especially in infants, people of advanced age, and immunocompromised hosts. In 2003, a novel HCoV strain was identified as the causative agent of the severe acute respiratory syndrome (SARS) epidemic that began in Asia in 2002. The strain has hence been referred to as SARS-CoV. In addition, as recently as September 2012, another novel HCoV, human betacoronavirus 2c EMC2012, was identified as being the cause of fever, renal failure, pneumonia, and severe respiratory distress in two patients in the Middle East. Phylogenetic analysis has revealed highly conserved sequences of ORF1ab, spike, nucleocapsid, and envelope protein genes, but not membrane protein genes, between human betacoronavirus 2c EMC2012 and SARS-CoV. This review focuses on the differences in the genomes of certain HCoV strains, the pathogenesis of said strains, and recent developments in the establishment of therapeutic agents that might aid in the treatment of patients with such infections.
has issue date	2013-02-01(xsd:dateTime)
bibo:doi	10.1016/j.biomed.2012.12.007
bibo:pmid	32289002
has license	no-cc
sha1sum (hex)	5c9372cbcf5acd3ce0e9ba3c3aa9e6a75bf9ed5a
schema:url	https://doi.org/10.1016/j.biomed.2012.12.007
resource representing a document's title	Human coronaviruses: Clinical features and phylogenetic analysis
has PubMed Central identifier	PMC7103958
has PubMed identifier	32289002
schema:publication	Biomedicine (Taipei)
resource representing a document's body	covid:5c9372cbcf5acd3ce0e9ba3c3aa9e6a75bf9ed5a#body_text
is schema:about of	named entity 'infection' named entity 'SARS-CoV' named entity 'pneumonia' named entity 'severe' named entity 'The strain' named entity 'BEGAN' named entity 'ADVANCED AGE' named entity 'CORONAVIRUS INFECTION' named entity 'CAUSE' named entity 'HCOV-OC43' named entity 'PEOPLE' named entity 'PHYLOGENETIC TREE' named entity 'IMMUNOCOMPROMISED' named entity 'REFERRED TO' named entity 'EPIDEMIC' named entity 'SEVERE' named entity 'FEVER' named entity 'HUMAN' named entity 'RESPIRATORY' named entity 'RENAL FAILURE' named entity 'INDUCED' named entity 'S T' named entity 'HUMAN' named entity 'HOSTS' named entity 'UPPER' named entity 'RECENTLY' named entity 'GASTROINTESTINAL TRACTS' named entity 'ASIA' named entity 'CORONAVIRUSES' named entity 'CLINICAL FEATURES' named entity 'SNEEZING' named entity 'COMMON' named entity 'RHINOVIRUS' named entity 'RESPIRATORY DISTRESS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'STRAINS' named entity 'LIMITING' named entity 'RHINORRHEA' named entity 'COUGH' named entity 'NON-' named entity 'ADDITION' named entity 'SARS-COV' named entity 'NASAL OBSTRUCTION' named entity 'INFECT' named entity 'FEBRILE SEIZURE' named entity 'SELF' named entity 'HCOV-229E' named entity 'SEPTEMBER' named entity 'CERTAIN' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'HUMAN CORONAVIRUS' named entity 'PATIENTS' named entity 'HCOV-NL63' named entity 'IDENTIFIED' named entity 'GENERALLY' named entity 'INFANTS' named entity 'HEALTHY' named entity 'BEING' named entity 'MANIFESTATIONS' named entity 'CAUSATIVE AGENT' named entity 'MIDDLE EAST' named entity 'ADULTS' named entity 'LOWER RESPIRATORY TRACT INFECTION' named entity '28I' named entity 'KEYWORDS' named entity 'PHYLOGENETIC ANALYSIS' named entity 'HCOV-HKU1' named entity 'COMMON COLD' named entity 'STRAIN' named entity 'HUMANS' named entity 'BRONCHITIS' named entity 'PNEUMONIA' named entity 'BETACORONAVIRUS' named entity 'NOVEL' named entity 'human' named entity 'betacoronavirus' named entity 'coronavirus' named entity 'human' named entity 'infection' named entity 'fever'

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