About: Early postmortem brain MRI findings in COVID-19 non-survivors

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Early postmortem brain MRI findings in COVID-19 non-survivors
Creator	Coolen, Tim Creteur, Jacques De Tiège, Xavier De Witte, ; Fabio, ; Gilles Naeije, ; Goffard, Jean-Christophe Goldman, Serge Henrard, Sophie Lolli, Valentina Rovaï, Antonin Sadeghi, Niloufar Taccone, Silvio Trotta, Nicola
Source	MedRxiv
abstract	Importance: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is considered to have potential neuro-invasiveness that might lead to acute brain disorders or contribute to respiratory distress in patients with coronavirus disease 2019 (COVID-19). Brain magnetic resonance imaging (MRI) data in COVID-19 patients are scarce due to difficulties to obtain such examination in infected unstable patients during the COVID-19 outbreak. Objective: To investigate the occurrence of structural brain abnormalities in non-survivors of COVID-19 in a virtopsy framework. Design: Prospective, case series study with postmortem brain MRI obtained early (<24h) after death. Setting: Monocentric study. Participants: From 31/03/2020 to 24/04/2020, consecutive decedents who fulfilled the following inclusion criteria were included: death <24 hours, SARS-CoV-2 detection on nasopharyngeal swab specimen, chest computerized tomographic (CT) scan suggestive of COVID-19, absence of known focal brain lesion, and MRI compatibility. Main Outcome(s) and Measure(s): Signs of acute brain injury and MRI signal abnormalities along the olfactory tract and brainstem were searched independently by 3 neuroradiologists, then reviewed with neurologists and clinicians. Results: Among the 62 patients who died from COVID-19 during the inclusion period, 19 decedents fulfilled inclusion criteria. Subcortical micro- and macro-bleeds (2 decedents), cortico-subcortical edematous changes evocative of posterior reversible encephalopathy syndrome (PRES, one decedent), and nonspecific deep white matter changes (one decedent) were observed. Asymmetric olfactory bulbs were found in 4 other decedents without downstream olfactory tract abnormalities. No brainstem MRI signal abnormality. Conclusions and Relevance: Postmortem brain MRI demonstrates hemorrhagic and PRES-related brain lesions in non-survivors of COVID-19 that might be triggered by the virus-induced endothelial disturbances. SARS-CoV-2-related olfactory impairment seems to be limited to olfactory bulbs. The absence of brainstem MRI abnormalities does not support a brain-related contribution to respiratory distress in COVID-19.
has issue date	2020-05-08(xsd:dateTime)
bibo:doi	10.1101/2020.05.04.20090316
has license	medrxiv
sha1sum (hex)	5c00dbfc952dd52ab10dffcfa521077d74597b54
schema:url	https://doi.org/10.1101/2020.05.04.20090316
resource representing a document's title	Early postmortem brain MRI findings in COVID-19 non-survivors
resource representing a document's body	covid:5c00dbfc952dd52ab10dffcfa521077d74597b54#body_text
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