About: The Multifaceted Poliovirus 2A Protease: Regulation of Gene Expression by Picornavirus Proteases

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About: The Multifaceted Poliovirus 2A Protease: Regulation of Gene Expression by Picornavirus Proteases Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Multifaceted Poliovirus 2A Protease: Regulation of Gene Expression by Picornavirus Proteases
Creator	Carrasco, Luis Castelló, Alfredo
source	PMC
abstract	After entry into animal cells, most viruses hijack essential components involved in gene expression. This is the case of poliovirus, which abrogates cellular translation soon after virus internalization. Abrogation is achieved by cleavage of both eIF4GI and eIF4GII by the viral protease 2A. Apart from the interference of poliovirus with cellular protein synthesis, other gene expression steps such as RNA and protein trafficking between nucleus and cytoplasm are also altered. Poliovirus 2A(pro) is capable of hydrolyzing components of the nuclear pore, thus preventing an efficient antiviral response by the host cell. Here, we compare in detail poliovirus 2A(pro) with other viral proteins (from picornaviruses and unrelated families) as regard to their activity on key host factors that control gene expression. It is possible that future analyses to determine the cellular proteins targeted by 2A(pro) will uncover other cellular functions ablated by poliovirus infection. Further understanding of the cellular proteins hydrolyzed by 2A(pro) will add further insight into the molecular mechanism by which poliovirus and other viruses interact with the host cell.
has issue date	2011-04-14(xsd:dateTime)
bibo:doi	10.1155/2011/369648
bibo:pmid	21541224
has license	no-cc
sha1sum (hex)	5bff40b0df656057c9db88470a3b84b40f0eeb28
schema:url	https://doi.org/10.1155/2011/369648
resource representing a document's title	The Multifaceted Poliovirus 2A Protease: Regulation of Gene Expression by Picornavirus Proteases
has PubMed Central identifier	PMC3085340
has PubMed identifier	21541224
schema:publication	J Biomed Biotechnol
resource representing a document's body	covid:5bff40b0df656057c9db88470a3b84b40f0eeb28#body_text
is schema:about of	named entity 'Poliovirus' named entity 'protein synthesis' named entity 'mechanism' named entity 'functions' named entity 'insight' named entity 'RNA' named entity 'INTERACT' named entity 'RNA' named entity 'HOST CELL' named entity 'INTERFERENCE' named entity 'MOLECULAR MECHANISM' named entity 'poliovirus' named entity 'hydrolyzing' named entity 'detail' named entity 'hijack' named entity 'viral' named entity 'expression' named entity 'internalization' named entity 'animal cells' named entity 'viral proteins' named entity 'host cell' named entity 'infection' named entity 'cytoplasm' named entity 'cellular functions' named entity 'poliovirus' named entity 'poliovirus' named entity 'host cell' named entity 'antiviral' named entity 'virus' named entity 'Proteases' named entity 'control' named entity 'Nup153' named entity 'picornaviruses' named entity 'protein synthesis' named entity 'trans' named entity 'protein sequence' named entity '80S' named entity 'assay' named entity 'PABP' named entity 'eIF4GI' named entity 'tRNA' named entity 'mRNA' named entity 'HIV-1 infection' named entity 'karyopherin' named entity 'poly(A) tail' named entity 'eIF4G' named entity 'HIV-1 protease' named entity 'Rae-1' named entity 'SIV' named entity 'mRNAs' named entity 'mRNA' named entity 'retroviruses' named entity 'cytoplasm' named entity 'protein synthesis' named entity 'mRNA' named entity 'influenza' named entity 'polyadenylated' named entity 'small ribosomal subunit' named entity 'eIF4G' named entity 'eIF4G' named entity 'dystrophin' named entity 'RNA' named entity 'IRF3' named entity 'p21-activated protein kinase' named entity 'nuclear import' named entity 'coxsackievirus' named entity 'translational machinery' named entity 'uridine' named entity 'mRNA' named entity 'specific role' named entity 'amino acids' named entity 'nuclear envelope' named entity 'endoplasmic reticulum' named entity 'polyprotein' named entity 'polypeptides' named entity 'HRV' named entity 'eIF4G' named entity 'picornaviruses' named entity 'radiolabeled' named entity 'hydrolysis'

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