About: Maternal and perinatal outcomes and pharmacological management of Covid-19 infection in pregnancy: a systematic review protocol

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About: Maternal and perinatal outcomes and pharmacological management of Covid-19 infection in pregnancy: a systematic review protocol Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Maternal and perinatal outcomes and pharmacological management of Covid-19 infection in pregnancy: a systematic review protocol
Creator	Ahmad, Shamsa Al Hail, Fatema Al Hail, Moza Bayo, Arabo Kassem, Wessam Nazar, Zachariah Pallivalapila, Abdulrouf Parappil, Hussain Rijims, Mohammed Stewart, Derek Tarannum, Asma Thomas, Binny
Source	Medline; PMC
abstract	BACKGROUND: Over 4.2 million confirmed cases and more than 285,000 deaths, COVID-19 pandemic continues to harm significant number of people worldwide. Several studies have reported the impact of COVID-19 in general population; however, there is scarcity of information related to pharmacological management and maternal and perinatal outcomes during the pandemic. Altered physiological, anatomical, and immunological response during pregnancy makes it more susceptible to infections. Furthermore, during pregnancy, a woman undergoes multiple interactions with the health care system that increases her chance of getting infected; therefore, managing pregnant population presents a unique challenge. RESEARCH QUESTIONS: What are the different clinical characteristics presented in maternal and perinatal population? What are the different maternal and perinatal outcome measures reported? What are the distinct therapeutic interventions reported to treat COVID-19? Is it safe to use “medications” used in the treatment of COVID-19 during antenatal, perinatal, postnatal, and breastfeeding? METHOD: The search will follow a comprehensive, sequential three step search strategy. Several databases relevant to COVID-19 and its impact on pregnancy including Medline, CINAHL, and LitCovid will be searched from the inception of the disease until the completion of data collection. The quality of this search strategy will be assessed using Peer Review of Electronic Search Strategies Evidence-Based Checklist (PRESS EBC). An eligibility form will be developed for a transparent screening and inclusion/exclusion of studies. All studies will be sent to RefWorks, and abstraction will be independently performed by two researchers. Risk of bias will be assessed using Cochrane Risk of Bias tool for randomized controlled trials, Newcastle–Ottawa Quality Assessment Scale for non-randomized studies, and for case reports, Murad et al. tool will be used. Decision to conduct meta-analysis will be based on several factors including homogeneity and outcome measures reported; otherwise, a narrative synthesis will be deemed appropriate. DISCUSSION: This systematic review will summarize the existing data on effect of COVID-19 on maternal and perinatal population. Furthermore, to the best of our knowledge, this is the first systematic review addressing therapeutic management and safety of medicines to treat COVID-19 during pregnancy and breastfeeding. SYSTEMATIC REVIEW REGISTRATION: This systematic review has been registered and published with Prospero (CRD42020172773).
has issue date	2020-07-18(xsd:dateTime)
bibo:doi	10.1186/s13643-020-01418-2
bibo:pmid	32682444
has license	cc-by
sha1sum (hex)	5ba31bc1cc77691925a0b716ba39ba9af4a86afb
schema:url	https://doi.org/10.1186/s13643-020-01418-2
resource representing a document's title	Maternal and perinatal outcomes and pharmacological management of Covid-19 infection in pregnancy: a systematic review protocol
has PubMed Central identifier	PMC7368633
has PubMed identifier	32682444
schema:publication	Syst Rev
resource representing a document's body	covid:5ba31bc1cc77691925a0b716ba39ba9af4a86afb#body_text
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