About: Cap‐Dependent Translation Initiation Factor eIF4E: An Emerging Anticancer Drug Target

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cap‐Dependent Translation Initiation Factor eIF4E: An Emerging Anticancer Drug Target
Creator	Jia, Yan Bitterman, Peter Polunovsky, Vitaly Wagner, Carston
Source	Medline; PMC
abstract	Cancer cells tend to be more highly dependent on cap‐dependent translation than normal tissues. Thus, proteins involved in the initiation of cap‐dependent translation have emerged as potential anti‐cancer drug targets. Cap‐dependent translation is initiated by the binding of the factor eIF4E to the cap domain of mRNA. Detailed x‐ray crystal and NMR structures are available for eIF4E in association with cap‐analogs, as well as domains of other initiation factors. This review will summarize efforts to design potential antagonist of eIF4E that could be used as new pharmacological tools and anti‐cancer agents and. Insights drawn from these studies should aid in the design of future inhibitors of eIF4E dependent translation initiation. © 2012 Wiley Periodicals, Inc. Med Res Rev., 32, No. 4, 786‐814, 2012
has issue date	2012-04-11(xsd:dateTime)
bibo:doi	10.1002/med.21260
bibo:pmid	22495651
has license	no-cc
sha1sum (hex)	5b9a8cc7bab9298897697a3e016ea64103630616
schema:url	https://doi.org/10.1002/med.21260
resource representing a document's title	Cap‐Dependent Translation Initiation Factor eIF4E: An Emerging Anticancer Drug Target
has PubMed Central identifier	PMC7168506
has PubMed identifier	22495651
schema:publication	Med Res Rev
resource representing a document's body	covid:5b9a8cc7bab9298897697a3e016ea64103630616#body_text
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