About: The Host Restriction Factor Interferon-Inducible Transmembrane Protein 3 Inhibits Vaccinia Virus Infection

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About: The Host Restriction Factor Interferon-Inducible Transmembrane Protein 3 Inhibits Vaccinia Virus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Host Restriction Factor Interferon-Inducible Transmembrane Protein 3 Inhibits Vaccinia Virus Infection
Creator	Li, Yi Liu, Wei Zhu, Na Wang, Tian Jin, Ningyi Tian, Mingyao Tan, Peng Jiang, Ying Xing, Junji He, Fuchu Bai, Jieying Du, Shouwen Li, Chang Li, Tiyuan Wang, Maopeng Wang, Yuhang Wu, Shipin Yin, Ronglan Zhu, Yilong Li, C Odendall, Charlotte Li, Y Li, Zhu Jiang, Wang Liu, Tan
Source	Medline; PMC
abstract	Interferons (IFNs) establish dynamic host defense mechanisms by inducing various IFN-stimulated genes that encodes many antiviral innate immune effectors. IFN-inducible transmembrane (IFITM) proteins have been identified as intrinsic antiviral effectors, which block the entry of a broad spectrum of enveloped RNA viruses by interrupting virus-endosomal fusion. However, antiviral activity of IFITM proteins against mammalian DNA virus has not been demonstrated till date. Here, we sought to investigate the antiviral activities and mechanisms of interferon-inducible transmembrane protein 3 (IFITM3) protein against poxvirus infection. Analysis of expression kinetics of cell endogenous IFITM3 protein indicated that vaccinia virus (VACV) infection suppressed its translation, which was independent of IRF3 phosphorylation triggered by VACV. Although silencing of endogenous IFITM proteins did not affect their baseline antiviral effects in the cell, it has reduced the IFN-α-mediated inhibition of VACV infection, and also modulated VACV-induced cell death. Moreover, we discovered that overexpression of IFITM3 significantly restricted VACV infection, replication and proliferation mainly by interfering with virus entry processes prior to the virus nucleocapsid entry into the cytoplasm. Interestingly, IFITM3 overexpression showed an impact on virus binding. Furthermore, IFITM3 interfered with the cytosolic entry of virus through low pH-dependent fashion. Taken together, our findings provide the first evidence of exogenously expressed IFITM3 protein restricting infection of an enveloped DNA virus, thus expanding their antiviral spectrum. This study further explores the complex mechanism and provides novel insights into the interaction between virus infection and host defense.
has issue date	2018-02-16(xsd:dateTime)
bibo:doi	10.3389/fimmu.2018.00228
bibo:pmid	29503647
has license	cc-by
sha1sum (hex)	5b8be7d97df4b06c42eedda3d997677d60100828
schema:url	https://doi.org/10.3389/fimmu.2018.00228
resource representing a document's title	The Host Restriction Factor Interferon-Inducible Transmembrane Protein 3 Inhibits Vaccinia Virus Infection
has PubMed Central identifier	PMC5820317
has PubMed identifier	29503647
schema:publication	Front Immunol
resource representing a document's body	covid:5b8be7d97df4b06c42eedda3d997677d60100828#body_text
is schema:about of	named entity 'identified' named entity 'This' named entity 'Here' named entity 'However' named entity 'infection' named entity 'poxvirus' named entity 'DNA virus' named entity 'transmembrane protein' named entity 'Transmembrane' covid:arg/5b8be7d97df4b06c42eedda3d997677d60100828 named entity 'restricting' named entity 'study' named entity 'innate immune' named entity 'Interferons' named entity 'proteins' named entity 'infection' named entity 'infection' named entity 'infection' named entity 'insights' named entity 'antiviral' named entity 'activities' named entity 'reduced' named entity 'genes' named entity 'Analysis' named entity 'phosphorylation' named entity 'vaccinia virus' named entity 'IFITM3' named entity 'nucleocapsid' named entity 'IFITM3' named entity 'host defense mechanisms' named entity 'IFITM3' named entity 'IFN' named entity 'protein' named entity 'virus' named entity 'exogenously' named entity 'antiviral' named entity 'virus' named entity 'phosphorylation' named entity 'Vaccinia Virus' named entity 'interferon' named entity 'RNA synthesis' named entity 'kidney' named entity 'optical density' named entity 'virions' named entity 'African green monkey' named entity 'Poxviruses' named entity 'Alexa Fluor' named entity 'IFITM3' named entity 'inoculation' named entity 'infection' named entity 'IFITM5' named entity 'late endosomal' named entity 'cell death' named entity 'endosomal' named entity 'viral particles' named entity 'IFITM3' named entity 'ISGs'

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