About: Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19
Creator	Puel, Anne Al-Mousawi, Ali Andersen, Nanna-Sophie Carter-Timofte, Freytag, Mette Gallego, Carlos Hait, Alon Jørgensen, Sofie Madalina, Elena Mogensen, Trine Rosenzweig, Sergio Thomsen, Michelle
source	Medline; PMC
abstract	Coronavirus disease-19 (COVID-19) describes a set of symptoms that develop following infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whilst COVID-19 disease is most serious in patients with significant co-morbidities, the reason for healthy individuals succumbing to fulminant infection is largely unexplained. In this review, we discuss the most recent findings in terms of clinical features and the host immune response, and suggest candidate immune pathways that may be compromised in otherwise healthy individuals with fulminating COVID-19. On the basis of this early knowledge we reason a potential genetic effect on host immune response pathways leading to increased susceptibility to SARS-CoV-2 infection. Understanding these pathways may help not only in unraveling disease pathogenesis, but also in suggesting targets for therapy and prophylaxis. Importantly such insight should instruct efforts to identify those at increased risk in order to institute preventative measures, such as prophylactic medication and/or vaccination, when such opportunities arise in the later phases of the current pandemic or during future similar pandemics.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.3389/fimmu.2020.01606
bibo:pmid	32695122
has license	cc-by
sha1sum (hex)	5b6daa833fbedb18c83007aef1eeb4f525c4cd1b
schema:url	https://doi.org/10.3389/fimmu.2020.01606
resource representing a document's title	Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19
has PubMed Central identifier	PMC7338588
has PubMed identifier	32695122
schema:publication	Front Immunol
resource representing a document's body	covid:5b6daa833fbedb18c83007aef1eeb4f525c4cd1b#body_text
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