About: Evaluation of oral administration of bacteriophages to neonatal calves: Phage survival and impact on fecal Escherichia coli

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of oral administration of bacteriophages to neonatal calves: Phage survival and impact on fecal Escherichia coli
Creator	Bicalho, M Bicalho, R Machado, V Nydam, D Santos, T
Source	Elsevier; Medline; PMC
abstract	Abstract Diarrhea is an important cause of morbidity and mortality in neonatal calves. Several enteropathogens are associated with diarrhea in young calves, with Enterotoxigenic Escherichia coli (ETEC) infection being the most common type of colibacillosis. The rise of antibiotic resistance in a number of medically important bacterial pathogens has revived interest in the use of bacteriophages as anti-bacterial therapeutic agents. Here we describe the results of a randomized, placebo-controlled, double-blinded study designed to evaluate the effect of an oral bacteriophage cocktail on fecal E. coli colony-forming units (CFU). Ten calves were enrolled in the study to either the bacteriophage group or the placebo group for 22 feedings. Calves in the bacteriophage treatment group (n=6) received a total of 106 plaque-forming units (PFU) (volume=5ml) of each of four bacteriophages while the placebo group (n=4) received only phosphate-buffered saline (5ml). Fresh fecal samples and blood samples were collected daily from each calf and analyzed for bacterial count and presence of bacteriophage. E. coli-infecting phages were recovered from all phage-treated calves at concentrations of 10² to 10³ PFU per gram of rectal contents, but none was detected in serum. Phage treatment caused a reduction in fecal E. coli when compared to the control group: the mean log CFU for the placebo-treated group was 9.25 (SE=0.42) versus 9.11 (SE=0.34) for the phage-treated group, but the difference was not statistically significant.
has issue date	2012-04-30(xsd:dateTime)
bibo:doi	10.1016/j.livsci.2011.12.007
bibo:pmid	32362952
has license	els-covid
sha1sum (hex)	5b431eadc74bec177c1ca41ac02ef8087263b29e
schema:url	https://doi.org/10.1016/j.livsci.2011.12.007
resource representing a document's title	Evaluation of oral administration of bacteriophages to neonatal calves: Phage survival and impact on fecal Escherichia coli
has PubMed Central identifier	PMC7185787
has PubMed identifier	32362952
schema:publication	Livestock Science
resource representing a document's body	covid:5b431eadc74bec177c1ca41ac02ef8087263b29e#body_text
is schema:about of	named entity 'IMPACT' named entity 'statistically' named entity 'samples' named entity 'study' named entity 'bacterial pathogens' named entity 'E. coli' named entity 'group' named entity 'bacteriophages' named entity 'Evaluation' named entity 'SURVIVAL' named entity 'NEONATAL' named entity 'ORAL ADMINISTRATION' named entity 'GRAM' named entity 'SAMPLES' named entity 'PHAGE' named entity 'ORAL' named entity 'HERE' named entity 'FECAL' named entity 'FRESH' named entity 'DOUBLE-BLINDED' named entity 'TREATED' named entity 'STUDY' named entity 'BUFFERED' named entity 'EITHER' named entity 'ANTIBIOTIC RESISTANCE' named entity 'YOUNG' named entity 'RANDOMIZED' named entity 'CFU' named entity 'MORBIDITY AND MORTALITY' named entity 'TYPE' named entity 'GROUP' named entity 'BUT' named entity 'PHAGE' named entity 'EFFECT' named entity 'STATISTICALLY SIGNIFICANT' named entity 'CONTROL GROUP' named entity 'ASSOCIATED WITH' named entity 'CALVES' named entity 'COLIBACILLOSIS' named entity 'OF EACH' named entity 'ANALYZED' named entity 'BLINDED STUDY' named entity 'ESCHERICHIA COLI' named entity 'BACTERIOPHAGES' named entity 'COLLECTED' named entity 'THERAPEUTIC AGENTS' named entity 'RESULTS' named entity 'BACTERIAL COUNT' named entity 'BACTERIAL PATHOGENS' named entity 'BLOOD SAMPLES' named entity 'E. COLI' named entity 'FECAL' named entity 'EVALUATION' named entity 'NEONATAL' named entity 'PFU' named entity 'TREATMENT' named entity '10%' named entity 'USE OF' named entity 'UNITS' named entity 'TOTAL' named entity 'DETECTED' named entity 'TREATMENT GROUP' named entity 'COMMON' named entity 'DIARRHEA' named entity 'DIFFERENCE' named entity 'PLACEBO-CONTROLLED' named entity 'CALVES' named entity 'CONCENTRATIONS' named entity 'ENTEROTOXIGENIC ESCHERICHIA COLI' named entity 'DAILY' named entity 'ANTI-BACTERIAL' named entity 'EVALUATE' named entity 'SERUM' named entity 'PLACEBO' named entity 'PHAGES ' named entity 'INFECTION' named entity 'RECOVERED'

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