About: Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID‐19

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About: Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID‐19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID‐19
Creator	Liu, Yan Wu, Dong Gao, Yong Wang, \| Han, Mingfeng Li, Xiuyong Li, Tuantuan Wang, Linding Xu, Yuanhong Zhu, Yulin
Source	Medline; PMC
abstract	The role of clinical laboratory data in the differential diagnosis of the severe forms of COVID‐19 has not been definitely established. The aim of this study was to look for the warning index in severe COVID‐19 patients. We investigated 43 adult patients with COVID‐19. The patients were classified into mild group (28 patients) and severe group (15 patients). A comparison of the hematological parameters between the mild and severe groups showed significant differences in interleukin‐6 (IL‐6), d‐dimer (d‐D), glucose, thrombin time, fibrinogen, and C‐reactive protein (P < .05). The optimal threshold and area under the receiver operator characteristic curve (ROC) of IL‐6 were 24.3 and 0.795 µg/L, respectively, while those of d‐D were 0.28 and 0.750 µg/L, respectively. The area under the ROC curve of IL‐6 combined with d‐D was 0.840. The specificity of predicting the severity of COVID‐19 during IL‐6 and d‐D tandem testing was up to 93.3%, while the sensitivity of IL‐6 and d‐D by parallel test in the severe COVID‐19 was 96.4%. IL‐6 and d‐D were closely related to the occurrence of severe COVID‐19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID‐19 patients, which has important clinical value.
has issue date	2020-04-10(xsd:dateTime)
bibo:doi	10.1002/jmv.25770
bibo:pmid	32181911
has license	no-cc
sha1sum (hex)	5b27b9e946f12a104c00e1f524a93a6efd449a03
schema:url	https://doi.org/10.1002/jmv.25770
resource representing a document's title	Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID‐19
has PubMed Central identifier	PMC7228247
has PubMed identifier	32181911
schema:publication	J Med Virol
resource representing a document's body	covid:5b27b9e946f12a104c00e1f524a93a6efd449a03#body_text
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