About: CD4–CD8-T cells contribute to the persistence of viral hepatitis by striking a delicate balance in immune modulation

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About: CD4–CD8-T cells contribute to the persistence of viral hepatitis by striking a delicate balance in immune modulation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CD4–CD8-T cells contribute to the persistence of viral hepatitis by striking a delicate balance in immune modulation
Creator	Guo, Wei Sun, Ying Luo, Xiaoping Ning, Qin Wang, Hongwu Xi, Dong Yan, Weiming Chen, Tao Han, Meifang Lu, Yulei Qin, Xiaomin Wang, Xiaojing Wu, Di Zhang, Jiangguo
Source	Elsevier; Medline; PMC
abstract	Abstract Viral hepatitis remains the most common cause of liver disease and a major public health problem. Here, we focus on the role of CD4 CD8 double negative T (DN T) cells involved in the mechanisms of viral persistence in hepatitis. C3H/HeJ mice infected with murine hepatitis virus strain 3 (MHV-3) were used to display chronic viral hepatitis. DN T cells dramatically increased in MHV-3 infected mice. Adoptive transfer of DN T cells from MHV-3 infected mice led to a significant increase in mice survival. The DN T cells with production of IFN-γ and IL-2 are able to kill virus-specific CD8+ T cells via the Fas/FasL dependent pathway. The delicate balance of multiple effects of DN T cells may lead to viral persistence in MHV-3 induced hepatitis. In short, our study identified DN T cells contributing to viral persistence in MHV-3 induced hepatitis in C3H/HeJ mice, which provides a rationale for modulating DN T cells for the management of viral hepatitis.
has issue date	2012-11-30(xsd:dateTime)
bibo:doi	10.1016/j.cellimm.2012.11.010
bibo:pmid	23261832
has license	els-covid
sha1sum (hex)	5b11bcba84104ee1180caaa51adc51bcefbc7dfb
schema:url	https://doi.org/10.1016/j.cellimm.2012.11.010
resource representing a document's title	CD4–CD8-T cells contribute to the persistence of viral hepatitis by striking a delicate balance in immune modulation
has PubMed Central identifier	PMC7094652
has PubMed identifier	23261832
schema:publication	Cellular Immunology
resource representing a document's body	covid:5b11bcba84104ee1180caaa51adc51bcefbc7dfb#body_text
is schema:about of	named entity 'STRIKING' named entity 'MHV' named entity 'CD4' named entity 'INCREASED' named entity 'ADOPTIVE TRANSFER' named entity 'PROVIDES' named entity 'SIGNIFICANT' named entity 'INVOLVED' named entity 'VIRUS' named entity 'LED' named entity 'OF LIVER DISEASE' named entity 'OUR' named entity 'TO DISPLAY' named entity 'VIRAL HEPATITIS' named entity 'SURVIVAL' named entity 'INFECTED' named entity 'CD4 CD8' named entity 'NEGATIVE' named entity 'HERE' named entity 'IFN' named entity 'PUBLIC HEALTH' named entity 'COMMON' named entity 'FOCUS' named entity 'BALANCE' named entity 'VIRAL HEPATITIS' named entity 'INCREASE' named entity 'EFFECTS' named entity 'KILL' named entity 'T CELLS' named entity 'PATHWAY' named entity 'HEALTH PROBLEM' named entity 'A MAJOR' named entity 'PRODUCTION' named entity 'PERSISTENCE' named entity 'CD8' named entity 'T CELLS' named entity 'IMMUNE MODULATION' named entity 'CONTRIBUTE ' named entity 'CONTRIBUTING' named entity 'DOUBLE' named entity 'MURINE HEPATITIS VIRUS STRAIN 3' named entity 'STUDY' named entity 'CD8' named entity 'INDUCED' named entity 'ROLE' named entity 'CELLS' named entity 'BALANCE' named entity 'C3H' named entity 'IDENTIFIED' named entity 'USED' named entity 'MODULATING' named entity 'FAS' named entity 'CAUSE' named entity 'SHORT' named entity 'MULTIPLE' named entity 'VIRAL PERSISTENCE' named entity 'IL-2' named entity 'MHV' named entity 'MECHANISMS' named entity 'DEPENDENT' named entity 'SPECIFIC' named entity 'HEPATITIS' named entity 'CHRONIC VIRAL HEPATITIS' named entity 'MICE' named entity 'RATIONALE' named entity 'LEAD' named entity 'MANAGEMENT' covid:arg/5b11bcba84104ee1180caaa51adc51bcefbc7dfb

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