About: Clinical Course and Factors Associated with Hospitalization and Critical Illness Among COVID‐19 Patients in Chicago, Illinois

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Clinical Course and Factors Associated with Hospitalization and Critical Illness Among COVID‐19 Patients in Chicago, Illinois
Creator	Zhang, Yanyu Hota, Bala Gottlieb, Michael Alan, J Beck, Todd Desai, Pankaja Frankenberger, Casey Sansom, Sarah Ward, Edward
source	Medline; PMC
abstract	BACKGROUND: SARS‐CoV‐2 is a global pandemic associated with significant morbidity and mortality. However, information from United States cohorts is limited. Understanding predictors of admission and critical illness in these patients is essential to guide prevention and risk stratification strategies. METHODS: This was a retrospective, registry‐based cohort study including all patients presenting to Rush University Medical Center in Chicago, Illinois with COVID‐19 from March 4(th), 2020 to June 21(st), 2020. Demographic, clinical, laboratory, and treatment data were obtained from the registry and compared between hospitalized and non‐hospitalized patients, as well as those with critical illness. We used logistic regression modeling to explore risk factors associated with hospitalization and critical illness. RESULTS: 8,673 COVID‐19 patients were included in the study, of whom 1,483 (17.1%) were admitted to the hospital and 528 (6.1%) were admitted to the intensive care unit. Risk factors for hospital admission included advanced age, male sex (OR 1.69; 95% CI 1.44‐1.98), Hispanic/Latino ethnicity (OR 1.52; 95% CI 1.18‐1.92), hypertension (OR 1.77; 95% CI 1.46‐2.16), diabetes mellitus (OR 1.84; 95% CI 1.53‐2.22), prior CVA (OR 3.20; 95% CI 1.99‐5.14), coronary artery disease (OR 1.45; 95% CI 1.03‐2.06), heart failure (OR 1.79; 95% CI 1.23‐2.61), chronic kidney disease (OR 2.60, 95% CI 1.77‐3.83), end‐stage renal disease (OR 2.22; 95% CI 1.12‐4.41), cirrhosis (OR 2.03; 95% CI 1.42‐2.91), fever (OR 1.43; 95% CI 1.19‐1.71), and dyspnea (OR 4.53; 95% CI 3.75‐5.47). Factors associated with critical illness included male sex (OR 1.45; 95% CI 1.12‐1.88), congestive heart failure (OR 1.45; 95% CI 1.00‐2.12), obstructive sleep apnea (OR 1.58; 95% CI 1.07‐2.33), bloodborne cancer (OR 3.53; 95% CI 1.26‐9.86), leukocytosis (OR 1.53; 95% CI 1.15‐2.17), elevated neutrophil‐to‐lymphocyte ratio (OR 1.61; 95% CI 1.20‐2.17), hypoalbuminemia (OR 1.80; 95% CI 1.39‐2.32), elevated AST (OR 1.66; 95% CI 1.20‐2.29), elevated lactate (OR 1.95; 95% CI 1.40‐2.73), elevated D‐Dimer (OR 1.44; 95% CI 1.05‐1.97), and elevated troponin (OR 3.65; 95% CI 2.03‐6.57). CONCLUSION: There are a number of factors associated with hospitalization and critical illness. Clinicians should consider these factors when evaluating patients with COVID‐19.
has issue date	2020-08-06(xsd:dateTime)
bibo:doi	10.1111/acem.14104
bibo:pmid	32762106
has license	no-cc
sha1sum (hex)	5adedbd2f38ff79ab602dd9b11df357130c2a032
schema:url	https://doi.org/10.1111/acem.14104
resource representing a document's title	Clinical Course and Factors Associated with Hospitalization and Critical Illness Among COVID‐19 Patients in Chicago, Illinois
has PubMed Central identifier	PMC7436503
has PubMed identifier	32762106
schema:publication	Acad Emerg Med
resource representing a document's body	covid:5adedbd2f38ff79ab602dd9b11df357130c2a032#body_text
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