About: Severe acute respiratory infection in children in a densely populated urban slum in Kenya, 2007

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About: Severe acute respiratory infection in children in a densely populated urban slum in Kenya, 2007–2011 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Severe acute respiratory infection in children in a densely populated urban slum in Kenya, 2007–2011
Creator	Olack, Beatrice Feikin, Daniel Schneider, Eileen Mott, Joshua Erdman, Dean Njuguna, Henry Montgomery, Joel Katz, Mark Fields, Barry Cosmas, Leonard Wamola, Newton Neatherlin, John Breiman, Robert Oberste, M Kariuki Njenga, M Williamson, John Odero, Kennedy Okoth, George Ondari, Daniel
Source	Medline; PMC
abstract	BACKGROUND: Reducing acute respiratory infection burden in children in Africa remains a major priority and challenge. We analyzed data from population-based infectious disease surveillance for severe acute respiratory illness (SARI) among children <5 years of age in Kibera, a densely populated urban slum in Nairobi, Kenya. METHODS: Surveillance was conducted among a monthly mean of 5,874 (range = 5,778-6,411) children <5 years old in two contiguous villages in Kibera. Participants had free access to the study clinic and their health events and utilization were noted during biweekly home visits. Patients meeting criteria for SARI (WHO-defined severe or very severe pneumonia, or oxygen saturation <90%) from March 1, 2007-February 28, 2011 had blood cultures processed for bacteria, and naso- and oro- pharyngeal swabs collected for quantitative real-time reverse transcription polymerase chain reaction testing for influenza viruses, parainfluenza viruses (PIV), respiratory syncytial virus (RSV), adenovirus, and human metapneumovirus (hMPV). Swabs collected during January 1, 2009 – February 28, 2010 were also tested for rhinoviruses, enterovirus, parechovirus, Mycoplasma pneumoniae, and Legionella species. Swabs were collected for simultaneous testing from a selected group of control-children visiting the clinic without recent respiratory or diarrheal illnesses. RESULTS: SARI overall incidence was 12.4 cases/100 person-years of observation (PYO) and 30.4 cases/100 PYO in infants. When comparing detection frequency in swabs from 815 SARI cases and 115 healthy controls, only RSV and influenza A virus were significantly more frequently detected in cases, although similar trends neared statistical significance for PIV, adenovirus and hMPV. The incidence for RSV was 2.8 cases/100 PYO and for influenza A was 1.0 cases/100 PYO. When considering all PIV, the rate was 1.1 case/100 PYO and the rate per 100 PYO for SARI-associated disease was 1.5 for adenovirus and 0.9 for hMPV. RSV and influenza A and B viruses were estimated to account for 16.2% and 6.7% of SARI cases, respectively; when taken together, PIV, adenovirus, and hMPV may account for >20% additional cases. CONCLUSIONS: Influenza viruses and RSV (and possibly PIV, hMPV and adenoviruses) are important pathogens to consider when developing technologies and formulating strategies to treat and prevent SARI in children.
has issue date	2015-02-25(xsd:dateTime)
bibo:doi	10.1186/s12879-015-0827-x
bibo:pmid	25879805
has license	cc-by
sha1sum (hex)	5abaf42063d64c1f006c8595b5769f8087cae69c
schema:url	https://doi.org/10.1186/s12879-015-0827-x
resource representing a document's title	Severe acute respiratory infection in children in a densely populated urban slum in Kenya, 2007–2011
has PubMed Central identifier	PMC4351931
has PubMed identifier	25879805
schema:publication	BMC Infect Dis
resource representing a document's body	covid:5abaf42063d64c1f006c8595b5769f8087cae69c#body_text
is schema:about of	named entity 'conducted' named entity 'respiratory illness' named entity 'Kibera' named entity 'access' named entity 'pneumonia' named entity 'Participants' named entity 'infectious disease' named entity 'events' named entity 'age' named entity 'severe' named entity 'Nairobi' named entity 'Africa' named entity 'health' named entity 'SARI' named entity 'acute respiratory infection' named entity 'Africa' named entity 'oxygen saturation' named entity 'infectious disease' named entity 'Nairobi' named entity 'SARI' named entity 'Severe acute respiratory infection' named entity 'Kenya' named entity 'difficulty breathing' named entity 'viral pathogens' named entity 'etiology' named entity 'pathogens' named entity 'Atlanta' named entity 'Kibera' named entity 'Delta method' named entity 'Odds ratios' named entity 'SARI' named entity 'asymptomatic' named entity 'epidemiology' named entity 'pneumonia' named entity 'prospective study' named entity 'Odds ratios' named entity 'virus' named entity 'SARI' named entity 'urban setting' named entity 'Blood cultures' named entity 'incidence rates' named entity 'malaria' named entity 'risk factors' named entity 'historical data' named entity 'hygiene' named entity 'atypical bacteria' named entity 'Africa' named entity 'non-attributable' named entity 'vaccine' named entity 'Nasopharyngeal' named entity 'ALRI' named entity 'SARI' named entity 'SARI' named entity 'pathogen' named entity 'etiologies' named entity 'respiratory illness' named entity 'enterovirus' named entity 'virus' named entity 'breastfeed' named entity 'influenza' named entity 'SARI' named entity 'oropharyngeal' named entity 'gene'

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