About: Clinical Course and Outcomes of Severe Covid-19: A National Scale Study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical Course and Outcomes of Severe Covid-19: A National Scale Study
Creator	Singer, Pierre King, Daniel Ben-Avi, Ronny Benov, Avi Chen, Jacob Epstein, Danny Fink, Noam Glassberg, Elon Matan, Moshe Miller, Asaf Amit, Moran Bader, Tarif Bar, Alon Ben-Ari, Anat Cohen, Barak Dahan, David Dvir, Ayana Fridrich, Lidar Gelman, Ram Jakobson, Daniel Karol, Dana Kesari, Shani Landau, Geva Lev, Shaul Rozenblat, Tal Sorkin, Alex Soroksky, Arie Sviri, Sigal Tsur, Avishai
Source	Medline; PMC
abstract	Knowledge of the outcomes of critically ill patients is crucial for health and government officials who are planning how to address local outbreaks. The factors associated with outcomes of critically ill patients with coronavirus disease 2019 (Covid-19) who required treatment in an intensive care unit (ICU) are yet to be determined. Methods: This was a retrospective registry-based case series of patients with laboratory-confirmed SARS-CoV-2 who were referred for ICU admission and treated in the ICUs of the 13 participating centers in Israel between 5 March and 27 April 2020. Demographic and clinical data including clinical management were collected and subjected to a multivariable analysis; primary outcome was mortality. Results: This study included 156 patients (median age = 72 years (range = 22–97 years)); 69% (108 of 156) were male. Eighty-nine percent (139 of 156) of patients had at least one comorbidity. One hundred three patients (66%) required invasive mechanical ventilation. As of 8 May 2020, the median length of stay in the ICU was 10 days (range = 0–37 days). The overall mortality rate was 56%; a multivariable regression model revealed that increasing age (OR = 1.08 for each year of age, 95%CI = 1.03–1.13), the presence of sepsis (OR = 1.08 for each year of age, 95%CI = 1.03–1.13), and a shorter ICU stay(OR = 0.90 for each day, 95% CI = 0.84–0.96) were independent prognostic factors. Conclusions: In our case series, we found lower mortality rates than those in exhausted health systems. The results of our multivariable model suggest that further evaluation is needed of antiviral and antibacterial agents in the treatment of sepsis and secondary infection.
has issue date	2020-07-18(xsd:dateTime)
bibo:doi	10.3390/jcm9072282
bibo:pmid	32708357
has license	cc-by
sha1sum (hex)	5ab5bf53e5b6ec3eb08457f84471612470164c28
schema:url	https://doi.org/10.3390/jcm9072282
resource representing a document's title	Clinical Course and Outcomes of Severe Covid-19: A National Scale Study
has PubMed Central identifier	PMC7408944
has PubMed identifier	32708357
schema:publication	J Clin Med
resource representing a document's body	covid:5ab5bf53e5b6ec3eb08457f84471612470164c28#body_text
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