About: Viral etiology, clinical and laboratory features of adult hemophagocytic lymphohistiocytosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral etiology, clinical and laboratory features of adult hemophagocytic lymphohistiocytosis
Creator	He, Ping Jiao, Xiaoyang Li, Yazhen Chang, Xiaolan Chen, Jinghong Fan, Zhichen Si, Mengya Wang, Xuehua Xie, Qindong
Source	Medline; PMC
abstract	Secondary hemophagocytic lymphohistiocytosis (SHLH) is a potentially fatal hyperinflammatory syndrome with a heterogeneous etiology and has nonspecific clinical and laboratory findings. The diagnosis and treatment of adult SHLH is challenging because the etiology of the disease is difficult to identify, and the majority of reported cases are pediatric patients. The aim of this study was to describe the etiology, clinical characteristics, and outcomes of adult SHLH. Fifty‐four adult patients who fulfilled the criteria of SHLH were enrolled in the study. Viral etiology, blood biomarkers, and clinical manifestations of SHLH were analyzed in these patients. Twenty‐four SHLH patients had viraemia, whereas 30 SHLH patients were secondary to other diseases. Epstein‐Barr virus (EBV) was the most common virus that associated SHLH among all viruses studied. Severe SHLH patients with EBV‐viraemia presented significantly high levels of ferritin, lactate dehydrogenase, aspartate transaminase (AST), and alanine transaminase (ALT). Positively relationships existed between EBV DNA titers and levels of AST and ALT (P < 0.05). The prognosis of SHLH patients with EBV viraemia was worse than that of non‐EBV SHLH and non‐viral SHLH. Our data reveal that EBV is the major pathogen in virus‐associated SHLH, and EBV load influence disease development in SHLH patients with EBV infection that prognosis is worse than other viruses associated SHLH. J. Med. Virol. 88:541–549, 2016. © 2015 Wiley Periodicals, Inc.
has issue date	2015-10-19(xsd:dateTime)
bibo:doi	10.1002/jmv.24359
bibo:pmid	26287378
has license	no-cc
sha1sum (hex)	5a8ac14f04b5b594cb931fd36b90931368368e88
schema:url	https://doi.org/10.1002/jmv.24359
resource representing a document's title	Viral etiology, clinical and laboratory features of adult hemophagocytic lymphohistiocytosis
has PubMed Central identifier	PMC7166822
has PubMed identifier	26287378
schema:publication	J Med Virol
resource representing a document's body	covid:5a8ac14f04b5b594cb931fd36b90931368368e88#body_text
is schema:about of	named entity 'presented' named entity 'heterogeneous' named entity 'manifestations' named entity 'pediatric' named entity 'Laboratory' named entity 'PRESENTED' named entity 'ADULT' named entity 'EBV' named entity 'OUTCOMES' named entity 'DISEASES' named entity 'ALT' named entity 'EBV INFECTION' named entity 'BIOMARKERS' named entity 'STUDY' named entity 'LACTATE DEHYDROGENASE' named entity 'describe' named entity 'patients' named entity 'Viral' named entity 'EBV' named entity 'ALT' named entity 'AST' named entity 'adult' named entity 'EBV' named entity 'etiology' named entity 'ferritin' named entity 'diseases' named entity 'EBV' named entity 'high' named entity 'prognosis' named entity 'EBV infection' named entity 'disease development' named entity 'viraemia' named entity 'alanine transaminase' named entity 'EBV' named entity 'clinical characteristics' named entity 'ferritin' named entity 'pathogen' named entity 'virus' named entity 'etiology' named entity 'EBV' named entity 'hemophagocytosis' named entity 'EBV' named entity 'AST' named entity 'Immunoglobulin' named entity 'prognosis' named entity 'EBV' named entity 'viral load' named entity 'LDH' named entity 'survival time' named entity 'immunosuppressed' named entity 'ferritin' named entity 'C-reactive protein' named entity 'case reports' named entity 'erythropoiesis' named entity 'complete blood count' named entity 'precursor cells' named entity 'EBV' named entity 'biomarkers' named entity 'histopathological' named entity 'biomarker' named entity 'serum' named entity 'viraemia' named entity 'Epstein-Barr virus' named entity 'EBV' named entity 'HPV' named entity 'virus' named entity 'EBV' named entity 'Ehrlichia chaffeensis' named entity 'AST and ALT' named entity 'proinflammatory cytokines' named entity 'viraemia' named entity 'alcoholic hepatitis' named entity 'granulocytes'

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