About: Myocardial injury is associated with in-hospital mortality of confirmed or suspected COVID-19 in Wuhan, China: A single center retrospective cohort study

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About: Myocardial injury is associated with in-hospital mortality of confirmed or suspected COVID-19 in Wuhan, China: A single center retrospective cohort study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Myocardial injury is associated with in-hospital mortality of confirmed or suspected COVID-19 in Wuhan, China: A single center retrospective cohort study
Creator	Li, Jing Zhang, Fan Liu, Juan Li, Liwei Gao, Peng Wu, Yonghong Chen, Taibo Cheng, Kangan Cheng, Zhongwei Fan, Hongru Fang, Quan Fang, Yong He, Liqun Pan, Wan Tian, Guowei Yang, Deyan Yi, Chunfeng
Source	MedRxiv
abstract	[Background] Since December 2019, a cluster of coronavirus disease 2019 (COVID-19) occurred in Wuhan, Hubei Province, China and spread rapidly from China to other countries. In-hospital mortality are high in severe cases and cardiac injury characterized by elevated cardiac troponin are common among them. The mechanism of cardiac injury and the relationship between cardiac injury and in-hospital mortality remained unclear. Studies focused on cardiac injury in COVID-19 patients are scarce. [Objectives] To investigate the association between cardiac injury and in-hospital mortality of patients with confirmed or suspected COVID-19. [Methods] Demographic, clinical, treatment, and laboratory data of consecutive confirmed or suspected COVID-19 patients admitted in Wuhan No.1 Hospital from 25th December, 2019 to 15th February, 2020 were extracted from electronic medical records and were retrospectively reviewed and analyzed. Univariate and multivariate Cox regression analysis were used to explore the risk factors associated with in-hospital death. [Results] A total of 110 patients with confirmed (n=80) or suspected (n=30) COVID-19 were screened and 48 patients (female 31.3%, mean age 70.58{+/-}13.38 year old) among them with high-sensitivity cardiac troponin I (hs-cTnI) test within 48 hours after admission were included, of whom 17 (17/48, 35.4%) died in hospital while 31 (31/48, 64.6%) were discharged or transferred to other hospital. High-sensitivity cardiac troponin I was levated in 13 (13/48, 27.1%) patents. Multivariate Cox regression analysis showed pulse oximetry of oxygen saturation (SpO2) on admission (HR 0.704, 95% CI 0.546-0.909, per 1% decrease, p=0.007), elevated hs-cTnI (HR 10.902, 95% 1.279-92.927, p=0.029) and elevated d-dimer (HR 1.103, 95%CI 1.034-1.176, per 1mg/L increase, p=0.003) on admission were independently associated with in-hospital mortality. [Conclusions] Cardiac injury defined by hs-cTnI elevation and elevated d-dimer on admission were risk factors for in-hospital death, while higher SpO2 could be seen as a protective factor, which could help clinicians to identify patients with adverse outcome at the early stage of COVID-19.
has issue date	2020-03-24(xsd:dateTime)
bibo:doi	10.1101/2020.03.21.20040121
has license	medrxiv
sha1sum (hex)	5a63aee4fec9b225c82e699d5a7403d81d14f4ea
schema:url	https://doi.org/10.1101/2020.03.21.20040121
resource representing a document's title	Myocardial injury is associated with in-hospital mortality of confirmed or suspected COVID-19 in Wuhan, China: A single center retrospective cohort study
resource representing a document's body	covid:5a63aee4fec9b225c82e699d5a7403d81d14f4ea#body_text
is schema:about of	named entity 'BACKGROUND' named entity 'INJURY' named entity 'STUDIES' named entity 'China' named entity 'Hubei Province, China' named entity 'Wuhan' named entity 'Myocardial injury' named entity 'retrospective cohort study' named entity 'Wuhan' named entity 'cTnI' named entity 'toxin' named entity 'COVID' named entity 'inflammatory response' named entity 'cTnI' named entity 'leukocytosis' named entity 'gastrointestinal discomfort' named entity 'inflammation' named entity 'vasoconstriction' named entity 'COVID' named entity 'infection' named entity 'Fever' named entity 'Wuhan' named entity 'COVID' named entity 'myocardium' named entity 'infection' named entity 'regression analysis' named entity 'vomiting' named entity 'SARS-CoV' named entity 'symptom' named entity 'dizziness' named entity 'infection' named entity 'coagulation abnormalities' named entity 'necrosis' named entity 'Wuhan' named entity 'coronavirus' named entity 'invasive mechanical ventilation' named entity 'World Health Organization' named entity 'atrial fibrillation' named entity 'IL-8' named entity 'preprint' named entity 'COVID' named entity 'Wuhan' named entity 'coagulation' named entity 'lymphocytopenia' named entity 'myocardium' named entity 'Cox regression' named entity 'atrial fibrillation' named entity '2019 novel coronavirus infection' named entity 'multiple organ dysfunction' named entity 'Kaplan-Meier curve' named entity 'platelet' named entity 'Wuhan' named entity 'SARS-CoV-2' named entity 'hypoxemic' named entity 'serum' named entity 'monocytes' named entity 'coronary perfusion' named entity 'cTnI' named entity 'coagulation cascade' named entity 'IL-6' named entity 'SARS-CoV-2' named entity 'cTnI' named entity 'SpO2' named entity 'older age' named entity 'respiratory infections' named entity 'infection' named entity 'increasing cases' named entity 'COVID' named entity 'COVID-19'

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