About: The role of human Metapneumovirus genetic diversity and nasopharyngeal viral load on symptom severity in adults

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About: The role of human Metapneumovirus genetic diversity and nasopharyngeal viral load on symptom severity in adults Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The role of human Metapneumovirus genetic diversity and nasopharyngeal viral load on symptom severity in adults
Creator	Kamarulzaman, Adeeba Chan, Chan, Yoke Chook, Jack Chow, Wei Hanafi, Nik Ng, Kim Oong, Xiang Pang, Yong Kok, Gan Keng Tee, Kok
Source	Medline; PMC
abstract	BACKGROUND: Human metapneumovirus (HMPV) is established as one of the causative agents of respiratory tract infections. To date, there are limited reports that describe the effect of HMPV genotypes and/or viral load on disease pathogenesis in adults. This study aims to determine the role of HMPV genetic diversity and nasopharyngeal viral load on symptom severity in outpatient adults with acute respiratory tract infections. METHODS: Severity of common cold symptoms of patients from a teaching hospital was assessed by a four-category scale and summed to obtain the total symptom severity score (TSSS). Association between the fusion and glycoprotein genes diversity, viral load (quantified using an improved RT-qPCR assay), and symptom severity were analyzed using bivariate and linear regression analyses. RESULTS: Among 81/3706 HMPV-positive patients, there were no significant differences in terms of demographics, number of days elapsed between symptom onset and clinic visit, respiratory symptoms manifestation and severity between different HMPV genotypes/sub-lineages. Surprisingly, elderly patients (≥65 years old) had lower severity of symptoms (indicated by TSSS) than young and middle age adults (p = 0.008). Nasopharyngeal viral load did not correlate with nor predict symptom severity of HMPV infection. Interestingly, at 3–5 days after symptom onset, genotype A-infected patients had higher viral load compared to genotype B (4.4 vs. 3.3 log(10) RNA copies/μl) (p = 0.003). CONCLUSIONS: Overall, HMPV genetic diversity and viral load did not impact symptom severity in adults with acute respiratory tract infections. Differences in viral load dynamics over time between genotypes may have important implications on viral transmission. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12985-018-1005-8) contains supplementary material, which is available to authorized users.
has issue date	2018-05-23(xsd:dateTime)
bibo:doi	10.1186/s12985-018-1005-8
bibo:pmid	29792212
has license	cc-by
sha1sum (hex)	59cbbd255acc779e36311d1c4f5be34bdc904888
schema:url	https://doi.org/10.1186/s12985-018-1005-8
resource representing a document's title	The role of human Metapneumovirus genetic diversity and nasopharyngeal viral load on symptom severity in adults
has PubMed Central identifier	PMC5966857
has PubMed identifier	29792212
schema:publication	Virol J
resource representing a document's body	covid:59cbbd255acc779e36311d1c4f5be34bdc904888#body_text
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