About: Human papillomavirus type 16 mutant E7 protein induces oncogenic transformation via up-regulation of cyclin A and cdc25A

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About: Human papillomavirus type 16 mutant E7 protein induces oncogenic transformation via up-regulation of cyclin A and cdc25A Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human papillomavirus type 16 mutant E7 protein induces oncogenic transformation via up-regulation of cyclin A and cdc25A
Creator	Zhao, Min Zhu, Li-Qin Liu, Jin-Hua Wu, Xin-Xing Xu, Yin-Yu Zhang, Yu-Liang
Source	PMC
abstract	A new mutant human papillomavirus type 16 E7 gene, termed HPV16 HBE7, was isolated from cervical carcinoma biopsy samples from patients in an area with high incidence of cervical cancer (Hubei province, China). A previous study showed that the HPV16 HBE7 protein was primarily cytoplasmic while wild-type HPV16 E7 protein, termed HPV16 WE7, was concentrated in the nucleus. With the aim of studying the biological functions of HPV16 HBE7, the transforming potential of HPV16 HBE7 in NIH/3T3 cells was detected through observation of cell morphology, cell prolieration assay and anchorage-independent growth assay. The effect of HPV16 HBE7 on cell cycle was examined by flow cytometry. Dual-luciferase reporter assay and RT-PCR were used to investigate the influence of HPV16 HBE7 protein on the expression of regulation factors associated with G1/S checkpoint. The results showed that HPV16 HBE7 protein, as well as HPV16 WE7 protein, held transformation activity. NIH/3T3 cells expressing HPV16 HBE7 could easily transition from G1 phase into S phase and expressed high level of cyclin A and cdc25A. These results indicated HPV16 mutant E7 protein, located in the cytoplasm, induces oncogenic transformation of NIH/3T3 cells via up-regulation of cyclin A and cdc25A
has issue date	2008-10-10(xsd:dateTime)
bibo:doi	10.1007/s12250-008-2966-3
has license	no-cc
sha1sum (hex)	59c725e7aa0e91f3d055521d1786091179015003
schema:url	https://doi.org/10.1007/s12250-008-2966-3
resource representing a document's title	Human papillomavirus type 16 mutant E7 protein induces oncogenic transformation via up-regulation of cyclin A and cdc25A
has PubMed Central identifier	PMC7091053
schema:publication	Virol Sin
resource representing a document's body	covid:59c725e7aa0e91f3d055521d1786091179015003#body_text
is schema:about of	named entity 'HUMAN PAPILLOMAVIRUS TYPE 16' named entity 'morphology' named entity 'type 16' named entity 'protein' named entity 'RT-PCR' named entity 'NIH' named entity 'investigate' named entity 'AREA' named entity 'CELL MORPHOLOGY' named entity 'TRANSFORMING' named entity 'NUCLEUS' named entity 'CYTOPLASMIC' named entity 'ISOLATED' named entity 'TRANSITION' named entity 'WILD-TYPE' named entity 'REGULATION' named entity 'USED' named entity 'E7 GENE' named entity 'CERVICAL CANCER' named entity 'EXPRESSION' named entity 'THESE' named entity 'TRANSFORMATION' named entity 'POTENTIAL' named entity 'DETECTED' named entity 'ANCHORAGE-INDEPENDENT GROWTH' named entity 'TO INVESTIGATE' named entity 'FLOW CYTOMETRY' named entity 'CELL PROLIFERATION ASSAY' named entity 'EXPRESSED' named entity 'CERVICAL CARCINOMA' named entity 'UP-REGULATION' named entity 'CHINA' named entity 'SAMPLES' named entity 'CONCENTRATED' named entity 'OBSERVATION' named entity 'HPV16 E7' named entity 'EASILY' named entity 'REPORTER ASSAY' named entity 'PROTEIN ' named entity 'MUTANT' named entity 'TRANSFORMATION' named entity 'E7 PROTEIN' named entity 'LOCATED IN' named entity 'E7 PROTEIN' named entity 'PROTEIN' named entity 'PROVINCE' named entity 'RT-PCR' named entity 'CYCLIN A' named entity 'CDC25A' named entity 'AIM' named entity 'BIOLOGICAL FUNCTIONS' named entity 'G1 PHASE' named entity 'CELLS' named entity 'ASSOCIATED WITH' named entity 'LUCIFERASE' named entity 'RESULTS' named entity 'HIGH' named entity 'ACTIVITY' named entity 'STUDY' named entity 'ON CELL' named entity 'CYCLIN A' named entity '2C CELL' named entity 'NIH' named entity 'S PHASE' named entity 'PREVIOUS' named entity 'BIOPSY' named entity 'INFLUENCE' named entity 'MUTANT' named entity 'HELD' named entity 'HIGH LEVEL' named entity 'EFFECT' named entity 'INCIDENCE' named entity 'NEW' named entity 'CYTOPLASM' named entity 'CELL CYCLE' named entity 'EXAMINED' named entity 'PATIENTS' named entity 'UP-REGULATION'

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