About: Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections

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About: Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections
Creator	Bachert, C Holtappels, · Höpken, K Höpken, · Van Kampen, M Van Kempen, · Wagenmann, ·
source	Medline; PMC
abstract	Upper respiratory tract infections (URTIs) are characterised by a neutrophilic mucosal infiltration. The purpose of this study was to investigate the time course of release of the cytokines/chemokines interleukins (IL) IL-1β, IL-1ra, tumour necrosis factor-α (TNF-α), IL-6, IL-8, interferon-γ (IFN-γ) and monocyte chemotactic protein (MCP-1), soluble intercellular adhesion molecule-1 (sICAM-1), myeloperoxidase (MPO) and bradykinin in nasal secretions of patients with a naturally acquired URTI. A total of 117 healthy adult volunteers were recruited for baseline nasal lavages, 39 of whom developed URTI symptoms within 6 months and returned to our centre within 48 h. Lavages were performed daily during the symptomatic period and 3 weeks thereafter, with symptoms no longer present. Compared to baseline, significantly elevated concentrations of total protein, bradykinin, IL-1β, TNF-α, IL-6, IL-8, MCP-1, IFN-γ, MPO and sICAM-1 were detected in nasal lavage fluids of symptomatic patients, whereas IL-1ra remained unaltered. All studied variables reached baseline 3 weeks after the URTI. Naturally acquired URTI represent a limited, neutrophilic inflammatory reaction, orchestrated by the release of pro-inflammatory cytokines and chemokines.
has issue date	2001-01-01(xsd:dateTime)
bibo:doi	10.1007/s004050100363
bibo:pmid	11724263
has license	no-cc
sha1sum (hex)	595d8e5713b0116c5fd508970bb6386341336ed6
schema:url	https://doi.org/10.1007/s004050100363
resource representing a document's title	Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections
has PubMed Central identifier	PMC7087684
has PubMed identifier	11724263
schema:publication	Eur Arch Otorhinolaryngol
resource representing a document's body	covid:595d8e5713b0116c5fd508970bb6386341336ed6#body_text
is schema:about of	named entity 'time' named entity 'bradykinin' named entity 'monocyte' named entity 'chemokines' named entity 'FLUIDS' named entity 'REPRESENT' named entity 'TOTAL PROTEIN' named entity 'IL-1ra' named entity 'MPO' named entity 'daily' named entity 'fluids' named entity 'infiltration' named entity 'nasal lavage' named entity 'baseline 3' named entity 'chemokines' named entity 'IL-8' named entity 'respiratory tract infections' named entity 'Upper respiratory tract' named entity 'Naturally' named entity 'acquired' named entity 'myeloperoxidase' named entity 'nasal secretions' named entity 'mucosal' named entity 'intercellular adhesion molecule-1' named entity 'IL-1β' named entity 'chemokines' named entity 'URTI' named entity 'IL-1ra' named entity 'TNF-α' named entity 'MCP-1' named entity 'baseline 3' named entity 'IL-1ra' named entity 'URTI' named entity 'total protein' named entity 'IL-6' named entity 'chemotactic protein' named entity 'monocyte' named entity 'neutrophilic' named entity 'TNF-α' named entity 'pro-inflammatory cytokines' named entity 'chemokines' named entity 'reached' named entity 'cytokine' named entity 'inflammatory mediator' named entity 'infection' named entity 'IL-8' named entity 'rhinitis' named entity 'bradykinin' named entity 'Minneapolis' named entity 'common cold' named entity 'chemokines' named entity 'cytokines' named entity 'cytokines' named entity 'epithelial' named entity 'chemokine' named entity 'nasal secretions' named entity 'IL-2' named entity 'IL-1' named entity 'rhinitis' named entity 'chemotaxis' named entity 'nasal secretions' named entity 'inflammatory response' named entity 'macrophages' named entity 'ICAM-1' named entity 'IFN-γ' named entity 'sICAM-1' named entity 'TNF-α' named entity 'pro-inflammatory cytokines' named entity 'MCP-1' named entity 'IFN-γ' named entity 'sICAM-1' named entity 'correlation' named entity 'soft palate' named entity 'nasal lavage' named entity 'University of Düsseldorf'

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