About: Immunodepletion with Hypoxemia: A Potential High Risk Subtype of Coronavirus Disease 2019

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Immunodepletion with Hypoxemia: A Potential High Risk Subtype of Coronavirus Disease 2019
Creator	Li, Yan Yuan, Yuan Jiang, Hong Yu, Lilei Fu, Aisi Lai, Yanqiu Liu, Tiangang Pan, Yuchen Shen, Gaigai Tong, Yongqing Wang, Yuhong Yu, Zhiyao Zhou, Xiaoya
source	MedRxiv
abstract	Background The outbreak of COVID-2019 is becoming a global public health emergency. Although its basic clinical features have been reported, the dynamic characteristics of immune system in COVID-2019 patients, especially those critical patients with refractory hypoxemia, are not yet well understood. We aim to describe the dynamic characteristics of immune system in 3 critical patients with refractory hypoxemia, and discuss the relationship between hypoxemia severity and immune cell levels, and the changes of gut microbes of COVID-2019 patient. Methods This is a retrospective study from 3 patients with 2019-nCoV infection admitted to Renmin Hospital of Wuhan University, a COVID-2019 designated hospital in Wuhan, from January 31 to February 6, 2020. All patients were diagnosed and classified based on the Diagnosis and Treatment of New Coronavirus Pneumonia (6th edition) published by the National Health Commission of China4. We recorded the epidemiological history, demographic features, clinical characteristics, symptoms and signs, treatment and clinical outcome in detail. Blood samples were collected and we determined the expression levels of immune cells (CD3+ T cells, CD4+ T cells, CD8+ T cells, CD19+ B cells, and CD16+56+ NK cells) in different time points. Nanopore Targeted Sequencing was used to determine the alterations of gut microbiota homeostasis. Results Apart from the clinical features described previously4, we found that four patients had decreased immune cells and refractory hypoxemia during the hospitalization, and the severity of hypoxemia was strongly correlated to the expression levels of immune cells. Additionally, we found that the proportion of probiotics was significantly reduced, such as Bifidobacterium, Lactobacillus, and Eubacterium, and the proportion of conditioned pathogenic bacteria was significantly increased, such as Corynebacterium of Actinobacteria and Ruthenibacterium of Firmicutes. Notably, all patients died. Conclusions We discussed the dynamic characteristics of host immune system and the imbalance of gut microbiota in 3 critical patients with COVID-2019. Hypoxemia severity was closely related with host immune cell levels, and the vicious circle between immune disorder and gut microbiota imbalance may be a high risk of fatal pneumonia. To the best of our knowledge, this is the first study which revealing that immunodepletion with refractory hypoxemia is a potential high risk subtype of COVID-2019 and the vicious circle between immune disorder and gut dysbiosis may be a high risk of fatal pneumonia.
has issue date	2020-03-06(xsd:dateTime)
bibo:doi	10.1101/2020.03.03.20030650
has license	medrxiv
sha1sum (hex)	594d23a412649df7dbfef5347a2a0c208ed4417d
schema:url	https://doi.org/10.1101/2020.03.03.20030650
resource representing a document's title	Immunodepletion with Hypoxemia: A Potential High Risk Subtype of Coronavirus Disease 2019
resource representing a document's body	covid:594d23a412649df7dbfef5347a2a0c208ed4417d#body_text
is schema:about of	named entity '2019' named entity 'Hypoxemia' named entity 'Potential' named entity 'HIGH RISK' named entity 'CORONAVIRUS DISEASE 2019' named entity 'OUTBREAK' named entity '2019' named entity 'POTENTIAL' named entity 'SUBTYPE' named entity 'HYPOXEMIA' named entity 'PUBLIC HEALTH' named entity 'BACKGROUND' named entity 'GLOBAL' named entity 'IMMUNODEPLETION' named entity 'refractory' named entity 'IgA' named entity 'Clinical studies' named entity 'infection' named entity 'IL-10' named entity 'NK cells' named entity 'viral pathogenesis' named entity 'expression levels' named entity 'COVID-2019' named entity 'COVID-2019' named entity 'refractory' named entity 'medRxiv' named entity 'peer-reviewed' named entity 'Bifidobacterium' named entity 'Kluyveromyces' named entity 'mucosal' named entity 'medical history' named entity 'immune cell' named entity 'Iran' named entity 'CD4+ T cells' named entity 'gut microbiota' named entity 'gut microbiota' named entity 'open reading frame' named entity 'infection' named entity 'preprint' named entity 'preprint' named entity 'hypoxemia' named entity 'preprint' named entity 'NOD-like receptor' named entity 'mechanical ventilation' named entity 'Wuhan University' named entity 'symptom' named entity 'Corynebacterium' named entity 'hypoxemia' named entity 'mitochondria' named entity 'antiviral' named entity 'gut microbiota' named entity 'refractory' named entity 'Oxygen mask' named entity 'myalgia' named entity 'hypoxia' named entity 'refractory' named entity 'COVID-2019' named entity 'Wuhan University' named entity 'gut microbiota' named entity 'extracorporeal membrane oxygenation' named entity 'alanine aminotransferase' named entity 'probiotics' named entity 'Firmicutes' named entity 'gut microbiota' named entity 'intravenous immunoglobulin' named entity 'immune disorder' named entity 'creatine' named entity 'Coronaviruses' named entity 'microbial' named entity 'aspartate aminotransferase' named entity 'gut microbiota' named entity 'Lactobacillus' named entity 'SaO2'

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